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AGFG2 ArfGAP with FG repeats 2 [ Homo sapiens (human) ]

Gene ID: 3268, updated on 1-Jun-2020

Summary

Official Symbol
AGFG2provided by HGNC
Official Full Name
ArfGAP with FG repeats 2provided by HGNC
Primary source
HGNC:HGNC:5177
See related
Ensembl:ENSG00000106351 MIM:604019
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRBL; RABR
Summary
This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Feb 2013]
Expression
Broad expression in salivary gland (RPKM 40.8), skin (RPKM 8.2) and 21 other tissues See more
Orthologs

Genomic context

See AGFG2 in Genome Data Viewer
Location:
7q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100539203..100568220)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100136834..100165843)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 416, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr7.3530 Neighboring gene insulin receptor substrate 3, pseudogene Neighboring gene Sin3A associated protein 25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies HRBL, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
Rev rev The proposed interaction of RAB-R with Rev is based on its similarity to HIV-1 Rev binding protein (hRip/RAB) PubMed
rev RAB-R is a proposed cellular cofactor for Rev function through a binding interaction with the Rev activation domain (amino acids 75-83) PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
membrane HDA PubMed 

General protein information

Preferred Names
arf-GAP domain and FG repeat-containing protein 2
Names
HIV-1 Rev-binding protein-like protein
Rev/Rex activation domain binding protein-related
arf-GAP domain and FG repeats-containing protein 2
nucleoporin
rev/Rex activation domain-binding protein related

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006076.5NP_006067.3  arf-GAP domain and FG repeat-containing protein 2

    See identical proteins and their annotated locations for NP_006067.3

    Status: REVIEWED

    Source sequence(s)
    AC069281, AK090744, AK314954, BC017329, BC047227, BF310674
    Consensus CDS
    CCDS5697.1
    UniProtKB/Swiss-Prot
    O95081
    UniProtKB/TrEMBL
    A4D2D6
    Related
    ENSP00000300176.4, ENST00000300176.9
    Conserved Domains (1) summary
    cl02464
    Location:40147
    ArfGap; Putative GTPase activating protein for Arf

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100539203..100568220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250306.2XP_005250363.1  arf-GAP domain and FG repeat-containing protein 2 isoform X1

    Conserved Domains (1) summary
    cl02464
    Location:40147
    ArfGap; Putative GTPase activating protein for Arf
  2. XM_017012114.1XP_016867603.1  arf-GAP domain and FG repeat-containing protein 2 isoform X4

    Related
    ENSP00000388594.1, ENST00000429987.1
  3. XM_017012113.1XP_016867602.1  arf-GAP domain and FG repeat-containing protein 2 isoform X3

  4. XM_017012112.1XP_016867601.1  arf-GAP domain and FG repeat-containing protein 2 isoform X2

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