U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AGFG1 ArfGAP with FG repeats 1 [ Homo sapiens (human) ]

Gene ID: 3267, updated on 6-Oct-2024

Summary

Official Symbol
AGFG1provided by HGNC
Official Full Name
ArfGAP with FG repeats 1provided by HGNC
Primary source
HGNC:HGNC:5175
See related
Ensembl:ENSG00000173744 MIM:600862; AllianceGenome:HGNC:5175
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRB; RAB; RIP
Summary
The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Expression
Broad expression in bone marrow (RPKM 27.1), testis (RPKM 16.3) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See AGFG1 in Genome Data Viewer
Location:
2q36.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (227472156..227561217)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (227954843..228043867)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (228336872..228425933)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124907993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17202 Neighboring gene uncharacterized LOC124907994 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:228335785-228336748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12399 Neighboring gene microRNA 5703 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:228451619-228452120 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12401 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57064 Neighboring gene small cysteine and glycine repeat containing 9 (pseudogene) Neighboring gene small cysteine and glycine repeat containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
ITGB5 and AGFG1 variants are associated with severity of airway responsiveness.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev Depletion of endogenous HIV-1 Rev binding protein (hRIP) by RNA interference results in the loss of viral replication in human cell lines and primary macrophages; virus production is restored to wild-type levels after reintroduction of hRIP protein PubMed
rev hRIP/Rab is known to interact with CRM1 (exportin 1) as part of its cofactor involvement with Rev-mediated nuclear export of HIV-1 mRNA PubMed
rev hRIP/Rab is a nucleoporin like protein that binds to the activation domain of HIV-1 Rev (amino acids 75-83) and acts as a cofactor for Rev-mediated nuclear export of HIV-1 mRNA PubMed
rev hRIP is an essential cellular HIV-1 Rev cofactor; abolishing hRIP activity with a dominant-negative mutant or RNA interference causes Rev-directed mRNAs to mislocalize and aberrantly accumulate at the nuclear periphery PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC116938, MGC116940, DKFZp686I15205

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding TAS
Traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in acrosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA export from nucleus TAS
Traceable Author Statement
more info
PubMed 
involved_in spermatid nucleus differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
part_of nuclear pore TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
arf-GAP domain and FG repeat-containing protein 1
Names
HIV-1 Rev-binding protein
Rab, Rev/Rex activation domain-binding protein
arf-GAP domain and FG repeats-containing protein 1
hRIP, Rev interacting protein
nucleoporin-like protein RIP
rev-interacting protein
rev/Rex activation domain-binding protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135187.2NP_001128659.1  arf-GAP domain and FG repeat-containing protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC097662, AC105286, AK097451, BQ016135, DB456989
    Consensus CDS
    CCDS46533.1
    UniProtKB/TrEMBL
    A0A0S2Z3Z1
    Related
    ENSP00000387282.2, ENST00000409979.6
    Conserved Domains (2) summary
    smart00105
    Location:14135
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    COG5347
    Location:8319
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
  2. NM_001135188.2NP_001128660.1  arf-GAP domain and FG repeat-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001128660.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC097662, AC105286, BC096272, BQ016135, DB456989
    Consensus CDS
    CCDS46534.1
    UniProtKB/TrEMBL
    A0A0S2Z3Y3
    Related
    ENSP00000387218.1, ENST00000409171.5
    Conserved Domains (2) summary
    smart00105
    Location:14135
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    COG5347
    Location:8306
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
  3. NM_001135189.2NP_001128661.1  arf-GAP domain and FG repeat-containing protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001128661.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AC097662, AC105286, BC096274, BQ016135, DB456989
    Consensus CDS
    CCDS46535.1
    UniProtKB/TrEMBL
    A0A0S2Z3Y3
    Related
    ENSP00000362775.3, ENST00000373671.7
    Conserved Domains (1) summary
    smart00105
    Location:14135
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
  4. NM_004504.5NP_004495.2  arf-GAP domain and FG repeat-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_004495.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC097662, AC105286, BC096273, BQ016135, DB456989
    Consensus CDS
    CCDS2467.1
    UniProtKB/Swiss-Prot
    B3KUL1, E9PHX7, P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11
    UniProtKB/TrEMBL
    A0A0S2Z3Y3, A0A0S2Z444
    Related
    ENSP00000312059.7, ENST00000310078.13
    Conserved Domains (2) summary
    smart00105
    Location:14135
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    COG5347
    Location:8306
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    227472156..227561217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    227954843..228043867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)