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RAB37 RAB37, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 326624, updated on 13-Mar-2020

Summary

Official Symbol
RAB37provided by HGNC
Official Full Name
RAB37, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:30268
See related
Ensembl:ENSG00000172794 MIM:609956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Rab proteins are low molecular mass GTPases that are critical regulators of vesicle trafficking. For additional background information on Rab proteins, see MIM 179508.[supplied by OMIM, Apr 2006]
Expression
Broad expression in spleen (RPKM 9.4), bone marrow (RPKM 7.1) and 20 other tissues See more
Orthologs

Genomic context

See RAB37 in Genome Data Viewer
Location:
17q25.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (74671131..74747335)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72667256..72743474)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CD300 molecule like family member d Neighboring gene chromosome 17 open reading frame 77 Neighboring gene uncharacterized LOC101928343 Neighboring gene CD300e molecule Neighboring gene uncharacterized LOC105371894 Neighboring gene CD300 molecule like family member f Neighboring gene uncharacterized LOC105371893 Neighboring gene SLC9A3 regulator 1 Neighboring gene microRNA 3615 Neighboring gene N-acetyltransferase 9 (putative)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
NHGRI GWA Catalog
Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of RAB37, member RAS oncogene family by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30284, FLJ32507

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
azurophil granule membrane TAS
Traceable Author Statement
more info
 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ras-related protein Rab-37
Names
RAB37, member of RAS oncogene family

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006638.3NP_001006639.1  ras-related protein Rab-37 isoform 2

    See identical proteins and their annotated locations for NP_001006639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter, 5' UTR, and alternate start codon, and includes an alternate coding exon, compared to variant 3. The resulting isoform (2) has a distinct and longer N-terminus, compared to isoform 3.
    Source sequence(s)
    AC016888, AK098068, BC016615
    Consensus CDS
    CCDS32722.1
    UniProtKB/Swiss-Prot
    Q96AX2
    UniProtKB/TrEMBL
    A0A024R8K6
    Related
    ENSP00000376389.5, ENST00000392613.10
    Conserved Domains (1) summary
    cd04112
    Location:31220
    Rab26; Rab GTPase family 26 (Rab26)
  2. NM_001163989.1NP_001157461.1  ras-related protein Rab-37 isoform 4

    See identical proteins and their annotated locations for NP_001157461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter, 5' UTR, and alternate start codon, and includes an alternate coding exon, compared to variant 3. The resulting isoform (4) has a distinct and longer N-terminus, compared to isoform 3.
    Source sequence(s)
    AC016888, AK303442, BC016615
    Consensus CDS
    CCDS54161.1
    UniProtKB/Swiss-Prot
    Q96AX2
    Related
    ENSP00000376390.4, ENST00000392614.8
    Conserved Domains (2) summary
    smart00175
    Location:36197
    RAB; Rab subfamily of small GTPases
    cd04112
    Location:36225
    Rab26; Rab GTPase family 26 (Rab26)
  3. NM_001163990.2NP_001157462.1  ras-related protein Rab-37 isoform 5

    See identical proteins and their annotated locations for NP_001157462.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents use of an alternate promoter, 5' UTR and alternate start codon, compared to variant 3. The resulting isoform (5) has a distinct and shorter N-terminus, compared to isoform 3.
    Source sequence(s)
    AC016888, AK296172, BC016615
    Consensus CDS
    CCDS54162.1
    UniProtKB/Swiss-Prot
    Q96AX2
    Related
    ENSP00000376388.3, ENST00000392612.7
    Conserved Domains (1) summary
    cd04112
    Location:30183
    Rab26; Rab GTPase family 26 (Rab26)
  4. NM_001330471.1NP_001317400.1  ras-related protein Rab-37 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC016888, AK057069, AK098068, AK296062, BC016615
    Consensus CDS
    CCDS82198.1
    UniProtKB/Swiss-Prot
    Q96AX2
    UniProtKB/TrEMBL
    B3KPZ5, B7Z3L0
    Related
    ENSP00000432086.1, ENST00000528438.5
  5. NM_175738.5NP_783865.1  ras-related protein Rab-37 isoform 3

    See identical proteins and their annotated locations for NP_783865.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes isoform 3.
    Source sequence(s)
    AC016888, AK290202, BC016615, DA164538
    Consensus CDS
    CCDS11703.1
    UniProtKB/Swiss-Prot
    Q96AX2
    Related
    ENSP00000383934.4, ENST00000402449.8
    Conserved Domains (2) summary
    smart00175
    Location:24185
    RAB; Rab subfamily of small GTPases
    cd04112
    Location:23213
    Rab26; Rab GTPase family 26 (Rab26)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    74671131..74747335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001006637.1: Suppressed sequence

    Description
    NM_001006637.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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