U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

H4c2 H4 clustered histone 2 [ Mus musculus (house mouse) ]

Gene ID: 326620, updated on 29-Oct-2022

Summary

Official Symbol
H4c2provided by MGI
Official Full Name
H4 clustered histone 2provided by MGI
Primary source
MGI:MGI:2448420
See related
Ensembl:ENSMUSG00000069266 AllianceGenome:MGI:2448420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H4c1; H4c3; H4c4; H4c6; H4c8; H4c9; H4c11; H4c12; H4c14; H4c16; H4f16; Hist1h4b
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See H4c2 in Genome Data Viewer
Location:
13; 13 A3.1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (23940920..23941369)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23756937..23757386)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene H2A clustered histone 4 Neighboring gene H3 clustered histone 2 Neighboring gene H4 clustered histone 1 Neighboring gene H3 clustered histone 1

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the H4c2 gene: The H4c2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of chromatin ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of CENP-A containing nucleosome ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone H4
Names
histone 1, H4b
histone cluster 1, H4b

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178193.2NP_835500.1  histone H4

    See identical proteins and their annotated locations for NP_835500.1

    Status: REVIEWED

    Source sequence(s)
    AL590388
    Consensus CDS
    CCDS26366.1
    UniProtKB/Swiss-Prot
    P62806, Q9D6Q8
    UniProtKB/TrEMBL
    A0A6P5R0T3, A0A8C6H4M7, B2RTM0
    Related
    ENSMUSP00000100030.3, ENSMUST00000102965.4
    Conserved Domains (1) summary
    PLN00035
    Location:1103
    PLN00035; histone H4; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    23940920..23941369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)