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ERAS ES cell expressed Ras [ Homo sapiens (human) ]

Gene ID: 3266, updated on 23-Aug-2020

Summary

Official Symbol
ERASprovided by HGNC
Official Full Name
ES cell expressed Rasprovided by HGNC
Primary source
HGNC:HGNC:5174
See related
Ensembl:ENSG00000187682 MIM:300437
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRAS2; HRASP
Summary
This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See ERAS in Genome Data Viewer
Location:
Xp11.23
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (48826513..48829869)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48684923..48688279)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene GATA binding protein 1 Neighboring gene histone deacetylase 6 Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor Neighboring gene translocase of inner mitochondrial membrane 17B Neighboring gene polyglutamine binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Pretreatment of cells with HIV-1 gp160 results in marked inhibition of tyrosine phosphorylation of p59(fyn), PLC-gamma1, ras activation, and TNF-alpha secretion in anti-CD3 mAb activated CD4+ T cells PubMed
env HIV-1 gp160 alone or CD4/gp160 cross-linking induces tyrosine phosphorylation of intracellular substrates p59fyn, zap 70, and p95vav and also leads to ras activation PubMed
Tat tat Knocking down oxidase Nox4 completely suppresses Tat-dependent Ras and ERK activation downstream of Rac1 and RhoA and blocks Tat-dependent proliferation PubMed
tat HIV-1 Tat activates the small GTPases Ras and Rac and the mitogen-activated protein kinase ERK when expressed in human endothelial cells; this effect is mediated through the arginine-glycine-aspartic (RGD) region of Tat PubMed
tat HIV-1 Tat-induced small GTPase Ras activation is mediated by tyrosine phosphorylation of Shc and recruitment of Grb2 in human endothelial cells PubMed
tat HIV-1 Tat induces ERK phosphorylation by the activation of the small GTPase Ras, but not the small GTPase Rac, in human endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126691, MGC126693

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
GTPase ERas
Names
E-Ras
embryonic stem cell-expressed Ras
small GTPase protein E-Ras
v-Ha-ras Harvey rat sarcoma viral oncogene homolog 2
v-Ha-ras Harvey rat sarcoma viral oncogene homolog pseudogene
NP_853510.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181532.3NP_853510.1  GTPase ERas precursor

    See identical proteins and their annotated locations for NP_853510.1

    Status: REVIEWED

    Source sequence(s)
    BC101642, HY043532
    Consensus CDS
    CCDS35246.1
    UniProtKB/Swiss-Prot
    Q7Z444
    Related
    ENSP00000490793.1, ENST00000636362.1
    Conserved Domains (1) summary
    cd04139
    Location:42201
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    48826513..48829869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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