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ADGRE4P adhesion G protein-coupled receptor E4, pseudogene [ Homo sapiens (human) ]

Gene ID: 326342, updated on 5-Jan-2022

Summary

Official Symbol
ADGRE4Pprovided by HGNC
Official Full Name
adhesion G protein-coupled receptor E4, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:19240
See related
Ensembl:ENSG00000268758 MIM:612305
Gene type
pseudo
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EMR4; FIRE; EMR4P; PGR16; GPR127
Summary
This gene is a member of the EGF-TM7 receptor gene family which is thought to play a role in leukocyte adhesion and migration. In other vertebrates, including nonhuman primates, this gene encodes a protein containing N-terminal EGF domains and a C-terminal transmembrane domain. Sequence evidence for the human gene, however, indicates nucleotide deletion in the genomic sequence would result in frameshift and early termination of translation. A protein expressed by this gene would be soluble rather than expressed on the cell surface. As the encoded protein has not been detected, this gene may represent a transcribed pseudogene. [provided by RefSeq, Aug 2008]
Expression
Broad expression in spleen (RPKM 5.6), appendix (RPKM 2.1) and 14 other tissues See more
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Genomic context

See ADGRE4P in Genome Data Viewer
Location:
19p13.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (6952500..6990846, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6952511..6990857, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene vav guanine nucleotide exchange factor 1 Neighboring gene Sharpr-MPRA regulatory region 13171 Neighboring gene uncharacterized LOC105372256 Neighboring gene adhesion G protein-coupled receptor E1 Neighboring gene uncharacterized LOC112268245 Neighboring gene microtubule affinity regulating kinase 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • EGF-TM7 receptor EMR4
  • G protein-coupled receptor 127
  • egf-like module containing, mucin-like, hormone receptor-like 4 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_024075.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AF489700
    Related
    ENST00000600751.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    6952500..6990846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080498.2: Suppressed sequence

    Description
    NM_001080498.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
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