Format

Send to:

Choose Destination

HPX hemopexin [ Homo sapiens (human) ]

Gene ID: 3263, updated on 13-Mar-2020

Summary

Official Symbol
HPXprovided by HGNC
Official Full Name
hemopexinprovided by HGNC
Primary source
HGNC:HGNC:5171
See related
Ensembl:ENSG00000110169 MIM:142290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HX
Summary
This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]
Expression
Restricted expression toward liver (RPKM 1209.1) See more
Orthologs

Genomic context

See HPX in Genome Data Viewer
Location:
11p15.4
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (6431049..6440987, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6452268..6462254, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene sphingomyelin phosphodiesterase 1 Neighboring gene amyloid beta precursor protein binding family B member 1 Neighboring gene Sharpr-MPRA regulatory region 8482 Neighboring gene tripartite motif containing 3 Neighboring gene Sharpr-MPRA regulatory region 6512 Neighboring gene ADP ribosylation factor interacting protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ56652

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heme transporter activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
heme metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme transport IEA
Inferred from Electronic Annotation
more info
 
hemoglobin metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
Inferred from Electronic Annotation
more info
 
positive regulation of immunoglobulin production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-gamma-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
blood microparticle HDA PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
collagen-containing extracellular matrix HDA PubMed 
endocytic vesicle lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hemopexin
Names
beta-1B-glycoprotein
epididymis secretory sperm binding protein
NP_000604.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000613.3NP_000604.1  hemopexin precursor

    See identical proteins and their annotated locations for NP_000604.1

    Status: REVIEWED

    Source sequence(s)
    AK313648, AV655383, BC005395
    Consensus CDS
    CCDS7763.1
    UniProtKB/Swiss-Prot
    P02790
    UniProtKB/TrEMBL
    Q9BS19
    Related
    ENSP00000265983.3, ENST00000265983.8
    Conserved Domains (1) summary
    cd00094
    Location:47231
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    6431049..6440987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center