FGF8 fibroblast growth factor 8 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: FGF8provided by VGNC
Official Full Name: fibroblast growth factor 8provided by VGNC
Primary source: VGNC:VGNC:28983
See related: EnsemblRapid:ENSBTAG00070009993
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: FGF6C
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 26

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	26	NC_037353.1 (22503903..22509709, complement)

Chromosome 26 - NC_037353.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FGF8 and FGF18 signal through divergent pathways in ovarian granulosa cells, despite reportedly similar receptor activation patterns.
Title: Divergence of intracellular signaling pathways and early response genes of two closely related fibroblast growth factors, FGF8 and FGF18, in bovine ovarian granulosa cells.
Genetic variability is an important component of the number of antral follicles in the bovine ovary.
Title: Single nucleotide polymorphisms in the bovine genome are associated with the number of oocytes collected during ovum pick up.
These results suggest that polymorphisms discovered in DECR1, CBFA2T1, and FGF8 may play a role in the lipid metabolism pathway affecting carcass quality traits in beef cattle.
Title: Polymorphisms in positional candidate genes on BTA14 and BTA26 affect carcass quality in beef cattle.

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General gene information

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Markers

Fgf8 (e-PCR), detects polymorphism
- UniSTS:506892

Fgf8 (e-PCR), detects polymorphism
- UniSTS:258274

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in dorsal/ventral pattern formation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in embryonic heart tube development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in heart morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in limb morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: fibroblast growth factor 8

Names: fibroblast growth factor 6C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.