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mbpa myelin basic protein a [ Danio rerio (zebrafish) ]

Gene ID: 326281, updated on 12-Sep-2024

Summary

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Official Symbol
mbpaprovided by ZNC
Official Full Name
myelin basic protein aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030128-2
See related
Ensembl:ENSDARG00000036186 AllianceGenome:ZFIN:ZDB-GENE-030128-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mbp; cb274; fj33b11; wu:fj33b11; wu:fq15b02; zgc:136630
Summary
Predicted to be a structural constituent of myelin sheath. Located in myelin sheath and plasma membrane. Is expressed in several structures, including EVL; male organism; nervous system; otic vesicle; and periderm. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MBP (myelin basic protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 19
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (21814626..21832487, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (22229724..22248302, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488507 Neighboring gene zinc finger protein 516 Neighboring gene uncharacterized LOC137488508 Neighboring gene galanin receptor 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. In vivo identification of small molecules mediating Gpr126/Adgrg6 signaling during Schwann cell development. Bradley EC, et al. Ann N Y Acad Sci, 2019 Nov. PMID 31529518, Free PMC Article
  2. Regeneration of myelin sheaths of normal length and thickness in the zebrafish CNS correlates with growth of axons in caliber. Karttunen MJ, et al. PLoS One, 2017. PMID 28542521, Free PMC Article
  3. Cre-inducible site-specific recombination in zebrafish oligodendrocytes. Pinzon-Olejua A, et al. Dev Dyn, 2017 Jan. PMID 27666728
  4. A novel model of demyelination and remyelination in a GFP-transgenic zebrafish. Fang Y, et al. Biol Open, 2014 Dec 19. PMID 25527642, Free PMC Article
  5. Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects. Buckley CE, et al. Neuropharmacology, 2010 Sep. PMID 20450924

See all (229) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes.
    Title: Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in vivo.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC136630

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables structural constituent of myelin sheath IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in myelin sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myelin basic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    21814626..21832487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002665557.5 → XP_002665603.1  myelin basic protein isoform X2

    UniProtKB/TrEMBL
    A0A8M1RKW5, F8W3M5
    Related
    ENSDARP00000124357.2, ENSDART00000149259.4
    Conserved Domains (1) summary
    pfam01669
    Location:1 → 120
    Myelin_MBP; Myelin basic protein

  2. XM_001340280.5 → XP_001340316.2  myelin basic protein isoform X1

    UniProtKB/TrEMBL
    A0A8M1PZE1, I3ITP3
    Related
    ENSDARP00000126314.1, ENSDART00000151442.3
    Conserved Domains (1) summary
    pfam01669
    Location:1 → 132
    Myelin_MBP; Myelin basic protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001020483.1: Suppressed sequence

    Description
    NM_001020483.1: This RefSeq was temporarily suppressed because the CDS was partial when compared to available protein (homology) data.
Nucleotide Protein
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