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mei-41 meiotic 41 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32608, updated on 12-Aug-2018

Summary

Official Symbol
mei-41provided by FlyBase
Official Full Name
meiotic 41provided by FlyBase
Primary source
FLYBASE:FBgn0004367
Locus tag
Dmel_CG4252
Gene type
protein coding
RNA name
meiotic 41
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4252; atr; ATR; CG4252; dATR; DmATR; Dmel\CG4252; Dmmei41; fs(1)M37; mei-195; Mei-41; Mei-41/DATR; mei41; MEI41; MEI41/FRP1; meiP41; mus(1)103; mus(1)104; mus-103; mus-104; mus103; mus104

Genomic context

See mei-41 in Genome Data Viewer
Location:
14C3-14C3; 1-53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16391698..16399850)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16285731..16293883)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene TH1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TNF-receptor-associated factor-like Neighboring gene Annexin B11

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Apoptosis - fly, organism-specific biosystem (from KEGG)
    Apoptosis - fly, organism-specific biosystemApoptosis, or programmed cell death, is a critical factor in homeostasis in all multicellular organisms, playing a crucial role in removing excess unwanted cells without stimulation of an immune resp...
  • Apoptosis - fly, conserved biosystem (from KEGG)
    Apoptosis - fly, conserved biosystemApoptosis, or programmed cell death, is a critical factor in homeostasis in all multicellular organisms, playing a crucial role in removing excess unwanted cells without stimulation of an immune resp...
  • Fanconi anemia pathway, organism-specific biosystem (from KEGG)
    Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
  • Fanconi anemia pathway, conserved biosystem (from KEGG)
    Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA damage checkpoint TAS
Traceable Author Statement
more info
PubMed 
DNA replication checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellularization TAS
Traceable Author Statement
more info
PubMed 
chromosome condensation IGI
Inferred from Genetic Interaction
more info
PubMed 
double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair via single-strand annealing IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair via synthesis-dependent strand annealing IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic development via the syncytial blastoderm TAS
Traceable Author Statement
more info
PubMed 
female meiosis chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
imaginal disc development TAS
Traceable Author Statement
more info
PubMed 
meiotic DNA double-strand break processing IDA
Inferred from Direct Assay
more info
PubMed 
mitotic DNA replication checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle checkpoint TAS
Traceable Author Statement
more info
PubMed 
oocyte fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic nuclear division IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of syncytial blastoderm mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
response to caffeine IGI
Inferred from Genetic Interaction
more info
PubMed 
response to radiation TAS
Traceable Author Statement
more info
PubMed 
telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
telomere maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
meiotic 41
Names
ATM-RAD3 related
CG4252-PA
drosophila ATR
mei-41-PA
meiotic-41
NP_523369.2

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16391698..16399850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078645.3NP_523369.2  meiotic 41 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523369.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VXG8
    Related
    FBpp0074047.1, FBtr0074271
    Conserved Domains (4) summary
    smart00802
    Location:9551060
    UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1
    cd00892
    Location:21812448
    PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins
    pfam02259
    Location:16531985
    FAT; FAT domain
    pfam02260
    Location:24862517
    FATC; FATC domain
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