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U2af50 U2 small nuclear riboprotein auxiliary factor 50 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32602, updated on 5-Jan-2023

Summary

Official Symbol
U2af50provided by FlyBase
Official Full Name
U2 small nuclear riboprotein auxiliary factor 50provided by FlyBase
Primary source
FLYBASE:FBgn0005411
Locus tag
Dmel_CG9998
See related
AllianceGenome:FB:FBgn0005411
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
9-21; CG9998; Dmel\CG9998; DmU2AF[50]; dU2AF50; DU2AF50; dU2AF[50]; dUTAf[50]; l(1)14Ca; l(1)14Cc; l(1)9-21; U2af; U2AF; U2AF 50; U2AF-50; U2AF50
Summary
Enables poly-pyrimidine tract binding activity. Involved in mRNA splicing, via spliceosome; nuclear export; and positive regulation of RNA export from nucleus. Located in nucleoplasm. Part of U2AF complex. Is expressed in adult brain cell body rind; adult head; and organism. Orthologous to human U2AF2 (U2 small nuclear RNA auxiliary factor 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See U2af50 in Genome Data Viewer
Location:
14B17-14B18; 1-53 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.46 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16356696..16359039, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16250729..16253072, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Dorsal switch protein 1 Neighboring gene small wing Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class Q Neighboring gene no on or off transient A

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the U2af50 gene: The U2af50 gene is conserved in human, dog, cow, mouse, rat, zebrafish, mosquito, C.elegans, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables poly-pyrimidine tract binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly-pyrimidine tract binding IDA
Inferred from Direct Assay
more info
PubMed 
enables pre-mRNA 3'-splice site binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U2AF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U2AF complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of commitment complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm HDA PubMed 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of precatalytic spliceosome HDA PubMed 
part_of spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
U2 small nuclear riboprotein auxiliary factor 50
Names
CG9998-PA
CG9998-PB
CG9998-PC
CG9998-PD
U2af50-PA
U2af50-PB
U2af50-PC
U2af50-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16356696..16359039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057543.4NP_476891.1  U2 small nuclear riboprotein auxiliary factor 50, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476891.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24562, Q9VXH2
    UniProtKB/TrEMBL
    A0A6P8KHG1, B4IF64, B4NUI9, B4PXS2, M9NDZ4
    Related
    FBpp0074013, FBtr0074234
    Conserved Domains (1) summary
    TIGR01642
    Location:39416
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
  2. NM_001258781.2NP_001245710.1  U2 small nuclear riboprotein auxiliary factor 50, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245710.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24562, Q9VXH2
    UniProtKB/TrEMBL
    A0A6P8KHG1, B4IF64, B4NUI9, B4PXS2, M9NDZ4
    Related
    FBpp0298007, FBtr0307178
    Conserved Domains (1) summary
    TIGR01642
    Location:39416
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
  3. NM_001258780.1NP_001245709.1  U2 small nuclear riboprotein auxiliary factor 50, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245709.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NH51
    Related
    FBpp0298006, FBtr0307177
    Conserved Domains (1) summary
    TIGR01642
    Location:1360
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
  4. NM_001258779.1NP_001245708.1  U2 small nuclear riboprotein auxiliary factor 50, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245708.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NF89
    Related
    FBpp0298005, FBtr0307176
    Conserved Domains (3) summary
    cd12230
    Location:103184
    RRM1_U2AF65; RNA recognition motif 1 found in U2 large nuclear ribonucleoprotein auxiliary factor U2AF 65 kDa subunit (U2AF65) and similar proteins
    cd12231
    Location:218294
    RRM2_U2AF65; RNA recognition motif 2 found in U2 large nuclear ribonucleoprotein auxiliary factor U2AF 65 kDa subunit (U2AF65) and similar proteins
    cd12232
    Location:328415
    RRM3_U2AF65; RNA recognition motif 3 found in U2 large nuclear ribonucleoprotein auxiliary factor U2AF 65 kDa subunit (U2AF65) and similar proteins