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CalpC Calpain C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32597, updated on 8-Feb-2025

Summary

Official Symbol
CalpCprovided by FlyBase
Official Full Name
Calpain Cprovided by FlyBase
Primary source
FLYBASE:FBgn0260450
Locus tag
Dmel_CG3692
See related
AllianceGenome:FB:FBgn0260450
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3692; Dmel\CG3692
Old locus tag
CG3692
Summary
Predicted to enable calcium ion binding activity. Located in cytoplasm. Is expressed in embryonic/larval salivary gland and organism. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; eosinophilic esophagitis; and muscular dystrophy. Orthologous to human CAPN13 (calpain 13); CAPN14 (calpain 14); and CAPN3 (calpain 3). [provided by Alliance of Genome Resources, Feb 2025]
Orthologs
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Genomic context

See CalpC in Genome Data Viewer
Location:
14B13-14B13; 1-53 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16325763..16328523)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16219796..16222556)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Strumpellin and WASH-interacting protein Neighboring gene Cyclophilin 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dorsal switch protein 1

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
NOT enables calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT enables calcium-dependent cysteine-type endopeptidase activity IKR
Inferred from Key Residues
more info
PubMed 
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
 
Process Evidence Code Pubs
NOT involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT involved_in proteolysis IKR
Inferred from Key Residues
more info
PubMed 
NOT involved_in proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
calpain C
Names
CG3692-PA
CalpC-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16325763..16328523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132890.3NP_573118.2  calpain C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573118.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86NA1, Q95R89, Q9VXH6
    UniProtKB/TrEMBL
    T2GFF8
    Related
    FBpp0074005
    Conserved Domains (3) summary
    COG5126
    Location:567648
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00044
    Location:7329
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cd00214
    Location:346483
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...