etfa electron transfer flavoprotein subunit alpha [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: etfaprovided by ZNC
Official Full Name: electron transfer flavoprotein subunit alphaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4449
See related: Ensembl:ENSDARG00000101631 AllianceGenome:ZFIN:ZDB-GENE-030131-4449
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb1020; wu:fd06h11
Summary: Predicted to enable electron transfer activity and flavin adenine dinucleotide binding activity. Acts upstream of or within animal organ morphogenesis; mitochondrion organization; and regulation of fatty acid beta-oxidation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; cardiovascular system; digestive system; musculature system; and nervous system. Used to study multiple acyl-CoA dehydrogenase deficiency. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFA (electron transfer flavoprotein subunit alpha). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	25	NC_133200.1 (35192398..35509148)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (32755485..32787247)

Chromosome 25 - NC_133200.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Electron Transfer Flavoprotein (ETF) alpha Controls Blood Vessel Development by Regulating Endothelial Mitochondrial Bioenergetics and Oxygen Consumption.
Title: Electron Transfer Flavoprotein (ETF) α Controls Blood Vessel Development by Regulating Endothelial Mitochondrial Bioenergetics and Oxygen Consumption.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables electron transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables electron transfer activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of electron transfer flavoprotein complex	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: electron transfer flavoprotein subunit alpha, mitochondrial

Names: dark xavier; electron-transfer-flavoprotein, alpha polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198909.1 → NP_944591.1 electron transfer flavoprotein subunit alpha, mitochondrial

See identical proteins and their annotated locations for NP_944591.1

Status: PROVISIONAL

Source sequence(s)

BC047845

UniProtKB/TrEMBL

A0A0G2L6T1, A0A8N7XJI1, Q6IQL1, Q7ZUS9

Related

ENSDARP00000140482.3, ENSDART00000162188.3

Conserved Domains (3) summary

PLN00022
Location:10 → 331

PLN00022; electron transfer flavoprotein subunit alpha; Provisional

cd01715
Location:22 → 190

ETF_alpha; The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an ...

pfam00766
Location:212 → 294

ETF_alpha; Electron transfer flavoprotein FAD-binding domain