get3 guided entry of tail-anchored proteins factor 3, ATPase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: get3provided by ZNC
Official Full Name: guided entry of tail-anchored proteins factor 3, ATPaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040625-120
See related: Ensembl:ENSDARG00000018190 AllianceGenome:ZFIN:ZDB-GENE-040625-120
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: asna1; trc40; zgc:56540; zgc:86799; wu:fd05d03
Summary: Predicted to enable ATP hydrolysis activity. Acts upstream of or within post-translational protein targeting to endoplasmic reticulum membrane and synapse assembly. Predicted to be located in endoplasmic reticulum and nucleolus. Predicted to be part of GET complex. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human GET3 (guided entry of tail-anchored proteins factor 3, ATPase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	1	NC_133176.1 (55461556..55476741)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (52137528..52151943)

Chromosome 1 - NC_133176.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fd05d03.x1 (e-PCR)
- UniSTS:204058

fc96b03.x1 (e-PCR)
- UniSTS:194845

fc64a01.y1 (e-PCR)
- UniSTS:194182

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on acid anhydrides	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in establishment of protein localization to membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in protein insertion into ER membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tail-anchored membrane protein insertion into ER membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GET complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATPase GET3

Names: arsA arsenite transporter, ATP-binding, homolog 1

NP_001002298.1

EC 7.3.2.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.