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Gbeta13F G protein beta subunit 13F [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32544, updated on 8-Feb-2025

Summary

Official Symbol
Gbeta13Fprovided by FlyBase
Official Full Name
G protein beta subunit 13Fprovided by FlyBase
Primary source
FLYBASE:FBgn0001105
Locus tag
Dmel_CG10545
See related
AllianceGenome:FB:FBgn0001105
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Liang-1.22; CG10545; clone 1.22; dgbeta; Dmel\CG10545; G b13F; G protein &bgr; G-beta; G-betab; Gb13F; Gbb; Gbeta; Gbeta13; gbeta13F; GNB1/2/3/4 like; G[[beta13F]]; G[[beta]]
Summary
Predicted to enable signaling receptor complex adaptor activity. Involved in several processes, including cell adhesion involved in heart morphogenesis; gastrulation; and mesectoderm development. Located in plasma membrane. Part of heterotrimeric G-protein complex. Is expressed in several structures, including brain; embryonic/larval midgut primordium; organism subdivision; sensory nervous system primordium; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease dominant intermediate F; artery disease (multiple); autosomal dominant intellectual developmental disorder 42; congenital stationary night blindness 1H; and hematologic cancer (multiple). Orthologous to several human genes including GNB1 (G protein subunit beta 1) and GNB4 (G protein subunit beta 4). [provided by Alliance of Genome Resources, Feb 2025]
Orthologs
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Genomic context

See Gbeta13F in Genome Data Viewer
Location:
13F16-13F16; 1-52 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15860115..15866175)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15754148..15760208)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Myb oncogene-like Neighboring gene AlkB Neighboring gene Glyceraldehyde 3 phosphate dehydrogenase 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables signaling receptor complex adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heterotrimeric G-protein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
G protein beta subunit 13F
Names
CG10545-PA
CG10545-PC
CG10545-PE
CG10545-PF
CG10545-PG
CG10545-PH
G protein beta subunit
G protein beta-subunit 13F
G-protein beta 13F
G[[beta]] brain
Gbeta13F-PA
Gbeta13F-PC
Gbeta13F-PE
Gbeta13F-PF
Gbeta13F-PG
Gbeta13F-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15860115..15866175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206739.2NP_996462.1  G protein beta subunit 13F, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996462.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P26308, Q9VXM8
    UniProtKB/TrEMBL
    A4V4I0
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]
  2. NM_206736.2NP_996459.1  G protein beta subunit 13F, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996459.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P26308, Q9VXM8
    UniProtKB/TrEMBL
    A4V4I0
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]
  3. NM_206737.2NP_996460.1  G protein beta subunit 13F, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996460.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P26308, Q9VXM8
    UniProtKB/TrEMBL
    A4V4I0
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]
  4. NM_206738.3NP_996461.1  G protein beta subunit 13F, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996461.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P26308, Q9VXM8
    UniProtKB/TrEMBL
    A4V4I0
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]
  5. NM_080351.7NP_525090.1  G protein beta subunit 13F, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525090.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P26308, Q9VXM8
    UniProtKB/TrEMBL
    A4V4I0
    Related
    FBpp0073921
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]
  6. NM_001316638.2NP_001303567.1  G protein beta subunit 13F, isoform H [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P26308, Q9VXM8
    UniProtKB/TrEMBL
    A4V4I0
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]