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Chc Clathrin heavy chain [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32537, updated on 26-Aug-2021

Summary

Official Symbol
Chcprovided by FlyBase
Official Full Name
Clathrin heavy chainprovided by FlyBase
Primary source
FLYBASE:FBgn0000319
Locus tag
Dmel_CG9012
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9012; chc; CHC; chc1; Cla; Clh; CLH; D-Chc; dCHC; Dmel\CG9012; l(1)13Fb; l(1)G0438; l(1)VI
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Genomic context

See Chc in Genome Data Viewer
Location:
13F5-13F7; 1-52 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15827986..15835490, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15722019..15729523, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44384 Neighboring gene scalloped Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR32582 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the Chc gene: The Chc gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.
  • Orthologs

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables clathrin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables clathrin light chain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dsRNA transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in liquid clearance, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oocyte microtubule cytoskeleton polarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pole plasm oskar mRNA localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor internalization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of tube length, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in secretory granule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sperm individualization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
part_of clathrin coat of coated pit IEA
Inferred from Electronic Annotation
more info
 
part_of clathrin coat of trans-Golgi network vesicle IEA
Inferred from Electronic Annotation
more info
 
part_of clathrin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of clathrin complex ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in clathrin-coated endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
clathrin heavy chain
Names
CG9012-PA
CG9012-PB
CG9012-PC
CG9012-PD
CG9012-PE
CG9012-PF
CG9012-PG
Chc-PA
Chc-PB
Chc-PC
Chc-PD
Chc-PE
Chc-PF
Chc-PG
clathrin
clathrin hc
clathrin heavy-chain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15827986..15835490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103524.2NP_001096994.1  clathrin heavy chain, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096994.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29742
    UniProtKB/TrEMBL
    X2JC31
    Related
    FBpp0111710, FBtr0112798
    Conserved Domains (5) summary
    smart00299
    Location:12751417
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:9841120
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:256288
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331353
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:364422
    Clathrin_H_link; Clathrin-H-link
  2. NM_001103523.2NP_001096993.1  clathrin heavy chain, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096993.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29742
    UniProtKB/TrEMBL
    X2JC31
    Related
    FBpp0111709, FBtr0112797
    Conserved Domains (5) summary
    smart00299
    Location:12751417
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:9841120
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:256288
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331353
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:364422
    Clathrin_H_link; Clathrin-H-link
  3. NM_057694.3NP_477042.1  clathrin heavy chain, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477042.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29742
    UniProtKB/TrEMBL
    X2JC31
    Related
    FBpp0073966, FBtr0074179
    Conserved Domains (5) summary
    smart00299
    Location:12751417
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:9841120
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:256288
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331353
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:364422
    Clathrin_H_link; Clathrin-H-link
  4. NM_001298371.1NP_001285300.1  clathrin heavy chain, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285300.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29742
    UniProtKB/TrEMBL
    X2JC31
    Related
    FBpp0308531, FBtr0339445
    Conserved Domains (5) summary
    smart00299
    Location:12751417
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:9841120
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:256288
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331353
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:364422
    Clathrin_H_link; Clathrin-H-link
  5. NM_206729.2NP_996452.1  clathrin heavy chain, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996452.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29742
    UniProtKB/TrEMBL
    X2JC31
    Related
    FBpp0089397, FBtr0074181
    Conserved Domains (5) summary
    smart00299
    Location:12751417
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:9841120
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:256288
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331353
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:364422
    Clathrin_H_link; Clathrin-H-link
  6. NM_206728.2NP_996451.1  clathrin heavy chain, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996451.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29742
    UniProtKB/TrEMBL
    X2JC31
    Related
    FBpp0089398, FBtr0074182
    Conserved Domains (5) summary
    smart00299
    Location:12751417
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:9841120
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:256288
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331353
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:364422
    Clathrin_H_link; Clathrin-H-link
  7. NM_167466.2NP_727901.1  clathrin heavy chain, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727901.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29742
    UniProtKB/TrEMBL
    X2JC31
    Related
    FBpp0073967, FBtr0074180
    Conserved Domains (5) summary
    smart00299
    Location:12751417
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:9841120
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:256288
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331353
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:364422
    Clathrin_H_link; Clathrin-H-link
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