chp1 calcineurin-like EF-hand protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: chp1provided by ZNC
Official Full Name: calcineurin-like EF-hand protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4086
See related: Ensembl:ENSDARG00000052859 AllianceGenome:ZFIN:ZDB-GENE-030131-4086
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: chp; zgc:63904; wu:fc69b04; si:dkey-41n20.1
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in membrane docking and negative regulation of calcineurin-NFAT signaling cascade. Predicted to act upstream of or within protein transport. Predicted to be located in cytoskeleton; endoplasmic reticulum; and nucleus. Predicted to be active in plasma membrane. Is expressed in pronephric duct and pronephros. Human ortholog(s) of this gene implicated in spastic ataxia. Orthologous to human CHP1 (calcineurin like EF-hand protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	13	NC_133188.1 (48625732..48659425, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (45035790..45063613, complement)

Chromosome 13 - NC_133188.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in membrane docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: calcineurin B homologous protein 1

Names: calcium binding protein P22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199715.1 → NP_956009.1 calcineurin B homologous protein 1

See identical proteins and their annotated locations for NP_956009.1

Status: PROVISIONAL

Source sequence(s)

BC054566

UniProtKB/TrEMBL

A0A8M1PED7, Q7T2F7

Related

ENSDARP00000110730.2, ENSDART00000130467.4

Conserved Domains (2) summary

COG5126
Location:1 → 181

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:113 → 179

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...