Polr3A RNA polymerase III subunit A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Polr3Aprovided by FlyBase
Official Full Name: RNA polymerase III subunit Aprovided by FlyBase
Primary source: FLYBASE:FBgn0030687
Locus tag: Dmel_CG17209
See related: AllianceGenome:FB:FBgn0030687
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: C160; CG17209; dC160; Dmel\CG17209; PolR3A; Rpc160; RpIIIC160; RPO31
Summary: Predicted to enable DNA binding activity. Predicted to contribute to RNA polymerase III activity. Involved in positive regulation of transcription by RNA polymerase III and positive regulation of translation. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 7 with or without oligodontia and-or hypogonadotropic hypogonadism and progeria. Orthologous to human POLR3A (RNA polymerase III subunit A). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.46	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (15762956..15769514)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (15656989..15663547)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Homologs of the Polr3A gene: The Polr3A gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase III activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to RNA polymerase III activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase III	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA transcription by RNA polymerase III	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of RNA polymerase III complex	ISS Inferred from Sequence or Structural Similarity more info

NP_001096987.2

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