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sephs1 selenophosphate synthetase 1 [ Danio rerio (zebrafish) ]

Gene ID: 324947, updated on 20-Feb-2026
Official Symbol
sephs1provided by ZNC
Official Full Name
selenophosphate synthetase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3670
See related
Ensembl:ENSDARG00000058292 AllianceGenome:ZFIN:ZDB-GENE-030131-3670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55304; wu:fc49b09
Summary
Predicted to enable protein heterodimerization activity; protein homodimerization activity; and selenide, water dikinase activity. Predicted to be involved in selenocysteine biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in nuclear membrane and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human SEPHS1 (selenophosphate synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See sephs1 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 18 NC_133193.1 (9547955..9560621, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 18 NC_007129.7 (8367602..8380262, complement)

Chromosome 18 - NC_133193.1Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB domain-containing protein 13 Neighboring gene carnitine palmitoyltransferase 1B (muscle) Neighboring gene BEN domain containing 7 Neighboring gene PRP18 pre-mRNA processing factor 18 homolog (yeast) Neighboring gene FERM domain containing 4A

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Sex-specific transcriptional responses of the zebrafish (Danio rerio) brain selenoproteome to acute sodium selenite supplementation. Benner MJ, et al. Physiol Genomics, 2013 Aug 1. PMID 23737534, Free PMC Article
  2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables selenide, water dikinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables selenide, water dikinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-selenocysteine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-selenocysteine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell redox homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
selenide, water dikinase 1
Names
selenium donor protein 1
selenophosphate synthase 1
NP_955995.2
XP_005159063.1
XP_068070826.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199701.2 → NP_955995.2  selenide, water dikinase 1

    See identical proteins and their annotated locations for NP_955995.2

    Status: VALIDATED

    Source sequence(s)
    BC045302, CN510578, CT658572, EB797523, EE312480
    UniProtKB/Swiss-Prot
    Q1LXT8, Q7ZW38
    UniProtKB/TrEMBL
    A0AB32TA65
    Related
    ENSDARP00000075586.4, ENSDART00000081143.6
    Conserved Domains (2) summary
    cd02195
    Location:20 → 357
    SelD; Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The ...
    TIGR00476
    Location:19 → 333
    selD; selenium donor protein

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133193.1 Reference GRCz12tu Primary Assembly

    Range
    9547955..9560621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159006.6 → XP_005159063.1  selenide, water dikinase 1 isoform X1

    See identical proteins and their annotated locations for XP_005159063.1

    UniProtKB/Swiss-Prot
    Q1LXT8, Q7ZW38
    UniProtKB/TrEMBL
    A0AB32TA65
    Related
    ENSDARP00000148109.1
    Conserved Domains (2) summary
    cd02195
    Location:20 → 357
    SelD; Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The ...
    TIGR00476
    Location:19 → 333
    selD; selenium donor protein

  2. XM_068214725.2 → XP_068070826.1  selenide, water dikinase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q1LXT8, Q7ZW38
    UniProtKB/TrEMBL
    A0AB32TA65
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZW38.2 GenPept UniProtKB/Swiss-Prot:Q7ZW38

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