gtf2b general transcription factor IIB [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gtf2bprovided by ZNC
Official Full Name: general transcription factor IIBprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3544
See related: Ensembl:ENSDARG00000103578 AllianceGenome:ZFIN:ZDB-GENE-030131-3544
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66258; wu:fc44c11
Summary: Predicted to enable several functions, including RNA polymerase II core promoter sequence-specific DNA binding activity; RNA polymerase II general transcription initiation factor activity; and TBP-class protein binding activity. Predicted to be involved in RNA polymerase II core complex assembly; RNA polymerase II preinitiation complex assembly; and transcriptional start site selection at RNA polymerase II promoter. Predicted to be located in chromosome. Predicted to be part of transcription preinitiation complex. Predicted to be active in nucleus. Orthologous to human GTF2B (general transcription factor IIB). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	2	NC_133177.1 (25736167..25748341, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (22480115..22492289, complement)

Chromosome 2 - NC_133177.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc44c11 (e-PCR)
- UniSTS:189165

fk71f05.x1 (e-PCR)
- UniSTS:201462

fa97c07 (e-PCR), detects polymorphism
- UniSTS:188919

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II core promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables TBP-class protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables TBP-class protein binding	IEA Inferred from Electronic Annotation more info
enables acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA-templated transcription initiation	IEA Inferred from Electronic Annotation more info
involved_in RNA polymerase II core complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transcription preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
involved_in transcriptional start site selection at RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription initiation factor IIB

NP_955991.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199697.1 → NP_955991.1 transcription initiation factor IIB

See identical proteins and their annotated locations for NP_955991.1

Status: PROVISIONAL

Source sequence(s)

BC055569

UniProtKB/TrEMBL

Q7SX98

Related

ENSDARP00000137822.1, ENSDART00000168022.2

Conserved Domains (3) summary

COG1405
Location:14 → 290

SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]

pfam00382
Location:121 → 191

TFIIB; Transcription factor TFIIB repeat

pfam08271
Location:14 → 53

TF_Zn_Ribbon; TFIIB zinc-binding