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HPGD 15-hydroxyprostaglandin dehydrogenase [ Homo sapiens (human) ]

Gene ID: 3248, updated on 12-Jan-2019

Summary

Official Symbol
HPGDprovided by HGNC
Official Full Name
15-hydroxyprostaglandin dehydrogenaseprovided by HGNC
Primary source
HGNC:HGNC:5154
See related
Ensembl:ENSG00000164120 MIM:601688
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGDH; PGDH1; PHOAR1; 15-PGDH; SDR36C1
Summary
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Expression
Biased expression in urinary bladder (RPKM 176.8), stomach (RPKM 67.9) and 11 other tissues See more
Orthologs

Genomic context

See HPGD in Genome Data Viewer
Location:
4q34.1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (174490177..174522898, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (175411328..175444049, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377547 Neighboring gene microRNA 4276 Neighboring gene uncharacterized LOC105377548 Neighboring gene zinc finger protein 772 pseudogene Neighboring gene uncharacterized LOC105377549

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
15-hydroxyprostaglandin dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
15-hydroxyprostaglandin dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
PubMed 
15-hydroxyprostaglandin dehydrogenase (NAD+) activity NAS
Non-traceable Author Statement
more info
PubMed 
15-hydroxyprostaglandin dehydrogenase (NAD+) activity TAS
Traceable Author Statement
more info
 
NAD binding IDA
Inferred from Direct Assay
more info
PubMed 
NAD+ binding IDA
Inferred from Direct Assay
more info
PubMed 
catalytic activity IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin E receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ductus arteriosus closure ISS
Inferred from Sequence or Structural Similarity
more info
 
female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
female pregnancy IDA
Inferred from Direct Assay
more info
PubMed 
kidney development IEA
Inferred from Electronic Annotation
more info
 
lipoxin biosynthetic process TAS
Traceable Author Statement
more info
 
lipoxygenase pathway TAS
Traceable Author Statement
more info
PubMed 
long-chain fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 
negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
ovulation ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
parturition IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
thrombin-activated receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol NAS
Non-traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Names
15-hydroxyprostaglandin dehydrogenase (NAD(+))
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
hydroxyprostaglandin dehydrogenase 15-(NAD)
prostaglandin dehydrogenase 1
short chain dehydrogenase/reductase family 36C member 1
NP_000851.2
NP_001139288.1
NP_001243230.1
NP_001243234.1
NP_001243235.1
NP_001243236.1
XP_011530209.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011689.1 RefSeqGene

    Range
    4744..37465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000860.6NP_000851.2  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1

    See identical proteins and their annotated locations for NP_000851.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC096751, AI435471, BC018986, DC420578
    Consensus CDS
    CCDS3821.1
    UniProtKB/Swiss-Prot
    P15428
    Related
    ENSP00000296522.6, ENST00000296522.10
    Conserved Domains (1) summary
    cd05323
    Location:6254
    ADH_SDR_c_like; insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs
  2. NM_001145816.2NP_001139288.1  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 2

    See identical proteins and their annotated locations for NP_001139288.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI435471, AK300940, BC018986, DC420578, X82460
    Consensus CDS
    CCDS54821.1
    UniProtKB/Swiss-Prot
    P15428
    Related
    ENSP00000296521.7, ENST00000296521.11
    Conserved Domains (1) summary
    cd05323
    Location:6168
    ADH_SDR_c_like; insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs
  3. NM_001256301.1NP_001243230.1  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 3

    See identical proteins and their annotated locations for NP_001243230.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences result in translation at a downstream start codon and an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 6 encode the same protein (isoform 3).
    Source sequence(s)
    AI435471, AK296642, BC018986
    Consensus CDS
    CCDS58933.1
    UniProtKB/Swiss-Prot
    P15428
    Related
    ENSP00000422418.1, ENST00000510901.5
    Conserved Domains (1) summary
    cl25409
    Location:1133
    SDR; Short-chain dehydrogenases/reductases (SDR)
  4. NM_001256305.1NP_001243234.1  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 4

    See identical proteins and their annotated locations for NP_001243234.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons in the 3' coding region, which results in a frameshift and early stop codon, compared to variant 1. It encodes isoform 4, which is shorter and contains a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI435471, AK058013, BC018986, DC420578, U63296
    Consensus CDS
    CCDS58935.1
    UniProtKB/Swiss-Prot
    P15428
    Related
    ENSP00000443644.1, ENST00000542498.5
    Conserved Domains (1) summary
    cl25409
    Location:6143
    SDR; Short-chain dehydrogenases/reductases (SDR)
  5. NM_001256306.1NP_001243235.1  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 5

    See identical proteins and their annotated locations for NP_001243235.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons in the coding region, compared to variant 1. It encodes isoform 5, which is shorter but contains the same N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AI435471, AK300125, BC018986, DC420578
    Consensus CDS
    CCDS58934.1
    UniProtKB/Swiss-Prot
    P15428
    Related
    ENSP00000398720.2, ENST00000422112.6
    Conserved Domains (1) summary
    cl25409
    Location:6186
    SDR; Short-chain dehydrogenases/reductases (SDR)
  6. NM_001256307.1NP_001243236.1  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 3

    See identical proteins and their annotated locations for NP_001243236.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a weak Kozak sequence and a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, to encode an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 6 encode the same protein (isoform 3).
    Source sequence(s)
    AC096751, AI435471, AK300524, BC018986, DC420578
    Consensus CDS
    CCDS58933.1
    UniProtKB/Swiss-Prot
    P15428
    Related
    ENSP00000438017.1, ENST00000541923.5
    Conserved Domains (1) summary
    cl25409
    Location:1133
    SDR; Short-chain dehydrogenases/reductases (SDR)
  7. NM_001363574.1NP_001350503.1  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC096751, BX396257
    Consensus CDS
    CCDS87280.1
    Conserved Domains (1) summary
    cl25409
    Location:6141
    SDR; Short-chain dehydrogenases/reductases (SDR)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    174490177..174522898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531907.2XP_011530209.1  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1

    UniProtKB/TrEMBL
    E9PBZ2
    Related
    ENSP00000420892.1, ENST00000504433.1
    Conserved Domains (1) summary
    cl25409
    Location:6141
    SDR; Short-chain dehydrogenases/reductases (SDR)

RNA

  1. XR_938728.2 RNA Sequence

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