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Top1 Topoisomerase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32458, updated on 10-Jan-2019

Summary

Official Symbol
Top1provided by FlyBase
Official Full Name
Topoisomerase 1provided by FlyBase
Primary source
FLYBASE:FBgn0004924
Locus tag
Dmel_CG6146
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6146; Dmel\CG6146; dTopoI; l(1)G0134; l(1)G0201; l(1)G0229; l(1)G0278; l(1)top1; top1; TOP1; TopI; topo I; Topo I; topoI; TopoI

Genomic context

See Top1 in Genome Data Viewer
Location:
13B6-13B6; 1-50 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.18 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15319479..15328029)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15213512..15222062)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene germ cell-expressed bHLH-PAS Neighboring gene ncRNA Neighboring gene mir-4957 stem loop Neighboring gene discontinuous actin hexagon Neighboring gene uncharacterized protein Neighboring gene Histone deacetylase 6 Neighboring gene ncRNA

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the Top1 gene: The Top1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

mobile_element

  • Loc: 15326740-15326927 mobile_element_type = transposon:I{}137

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA topoisomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA topoisomerase type I activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topoisomerase type I activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topological change IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topological change IDA
Inferred from Direct Assay
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
instar larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IMP
Inferred from Mutant Phenotype
more info
PubMed 
oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol HDA PubMed 
nuclear euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
polytene chromosome IDA
Inferred from Direct Assay
more info
PubMed 
polytene chromosome puff IDA
Inferred from Direct Assay
more info
PubMed 
replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
topoisomerase 1
Names
CG6146-PA
CG6146-PB
CG6146-PC
CG6146-PD
CG6146-PE
Top 1
Top1-PA
Top1-PB
Top1-PC
Top1-PD
Top1-PE
topoisomerase I
topoisomerase1
type I topoisomerase
NP_001014742.1
NP_001245679.1
NP_001285267.1
NP_511161.2
NP_727841.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15319479..15328029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078606.4NP_511161.2  topoisomerase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511161.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30189
    UniProtKB/TrEMBL
    Q494M1
    Related
    FBpp0073822, FBtr0074005
    Conserved Domains (4) summary
    smart00435
    Location:585946
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:441655
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    pfam01028
    Location:657859
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:905972
    Topo_C_assoc; C-terminal topoisomerase domain
  2. NM_001014742.2NP_001014742.1  topoisomerase 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014742.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30189
    UniProtKB/TrEMBL
    Q494M1
    Related
    FBpp0099689, FBtr0100294
    Conserved Domains (4) summary
    smart00435
    Location:585946
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:441655
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    pfam01028
    Location:657859
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:905972
    Topo_C_assoc; C-terminal topoisomerase domain
  3. NM_001258750.2NP_001245679.1  topoisomerase 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245679.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDX3
    Related
    FBpp0300905, FBtr0308699
    Conserved Domains (4) summary
    smart00435
    Location:581942
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:437651
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    pfam01028
    Location:653855
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:901968
    Topo_C_assoc; C-terminal topoisomerase domain
  4. NM_167435.3NP_727841.1  topoisomerase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727841.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IR39
    Related
    FBpp0073823, FBtr0074006
    Conserved Domains (4) summary
    smart00435
    Location:192553
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:48262
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    pfam01028
    Location:264466
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:512579
    Topo_C_assoc; C-terminal topoisomerase domain
  5. NM_001298338.1NP_001285267.1  topoisomerase 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285267.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JKD2
    Related
    FBpp0309379, FBtr0340434
    Conserved Domains (4) summary
    smart00435
    Location:204565
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:60274
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    pfam01028
    Location:276478
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:524591
    Topo_C_assoc; C-terminal topoisomerase domain
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