Format

Send to:

Choose Destination

hiw highwire [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32429, updated on 19-Oct-2021

Summary

Official Symbol
hiwprovided by FlyBase
Official Full Name
highwireprovided by FlyBase
Primary source
FLYBASE:FBgn0030600
Locus tag
Dmel_CG32592
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32592; CG9041; CG9049; Dmel\CG32592; Hiw; HIW
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See hiw in Genome Data Viewer
Location:
13A5-13A8; 1-49 cM
Exon count:
23
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15010137..15063429, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14904170..14957462, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ether a go-go Neighboring gene ben Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B18 subunit Neighboring gene opossum Neighboring gene doppelganger von brummer

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

mobile_element

  • Loc: c15018073-15017993 mobile_element_type = transposon:INE-1{}3058
  • Loc: c15048601-15047992 mobile_element_type = transposon:HB{}134

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding ISM
Inferred from Sequence Model
more info
PubMed 
Process Evidence Code Pubs
involved_in adult walking behavior NAS
Non-traceable Author Statement
more info
PubMed 
involved_in autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in locomotion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic assembly at neuromuscular junction TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of terminal button organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to axon injury IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synapse organization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
highwire
Names
CG32592-PA
CG32592-PB
hiw-PA
hiw-PB

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15010137..15063429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298329.1NP_001285258.1  highwire, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285258.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NB71
    UniProtKB/TrEMBL
    X2JF19
    Related
    FBpp0311921, FBtr0346087
    Conserved Domains (4) summary
    pfam00415
    Location:9851031
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam08005
    Location:14371585
    PHR; PHR domain
    pfam13540
    Location:968997
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    pfam13639
    Location:49895042
    zf-RING_2; Ring finger domain
  2. NM_078604.4NP_511159.3  highwire, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511159.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NB71
    UniProtKB/TrEMBL
    X2JF19
    Related
    FBpp0073787, FBtr0073970
    Conserved Domains (4) summary
    pfam00415
    Location:9851031
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam08005
    Location:14371585
    PHR; PHR domain
    pfam13540
    Location:968997
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    pfam13639
    Location:49895042
    zf-RING_2; Ring finger domain
Support Center