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fanci FA complementation group I [ Danio rerio (zebrafish) ]

Gene ID: 324185, updated on 9-Sep-2025
Official Symbol
fanciprovided by ZNC
Official Full Name
FA complementation group Iprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2905
See related
Ensembl:ENSDARG00000026224 AllianceGenome:ZFIN:ZDB-GENE-030131-2905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc21c10; wu:fc21c10; zgc:152941
Summary
Predicted to enable DNA polymerase binding activity. Predicted to act upstream of or within DNA repair. Is expressed in central nervous system; head; heart; pectoral fin; and rostral blood island. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group I; and female breast cancer. Orthologous to human FANCI (FA complementation group I). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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Location:
chromosome: 25
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 25 NC_133200.1 (9247956..9280330)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 25 NC_007136.7 (8447565..8479171)

Chromosome 25 - NC_133200.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141380891 Neighboring gene mucin 5.1, oligomeric mucus/gel-forming Neighboring gene mucin 5.2 Neighboring gene polymerase (DNA directed), gamma Neighboring gene transfer RNA arginine (anticodon UCG) Neighboring gene uncharacterized LOC137489327 Neighboring gene microRNA 9-3

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. FANCI functions as a repair/apoptosis switch in response to DNA crosslinks. Shah RB, et al. Dev Cell, 2021 Aug 9. PMID 34256011, Free PMC Article
  2. The Fanconi anemia/BRCA gene network in zebrafish: embryonic expression and comparative genomics. Titus TA, et al. Mutat Res, 2009 Jul 31. PMID 19101574, Free PMC Article
  3. Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility. Ramanagoudr-Bhojappa R, et al. PLoS Genet, 2018 Dec. PMID 30540754, Free PMC Article
  4. Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. Shin U, et al. DNA Repair (Amst), 2021 Nov. PMID 34390914
  5. Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish. Ren M, et al. Biomedicines, 2024 Dec 26. PMID 39857604, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC152941

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA polymerase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
Preferred Names
Fanconi anemia group I protein
Names
Fanconi anemia, complementation group I

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077312.2 → NP_001070780.2  Fanconi anemia group I protein

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000025
    UniProtKB/TrEMBL
    A0A8M1NA61, F1R3B9
    Related
    ENSDARP00000116242.1, ENSDART00000142090.3
    Conserved Domains (2) summary
    cd11720
    Location:47 → 1295
    FANCI; Fanconi anemia I protein
    pfam14674
    Location:7 → 59
    FANCI_S1-cap; FANCI solenoid 1 cap

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133200.1 Reference GRCz12tu Primary Assembly

    Range
    9247956..9280330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073941745.1 → XP_073797846.1  Fanconi anemia group I protein isoform X2

    UniProtKB/TrEMBL
    A0A8M1NA61, F1R3B9

  2. XM_021470451.2 → XP_021326126.1  Fanconi anemia group I protein isoform X1

    UniProtKB/TrEMBL
    A0A8M9PUU2
    Related
    ENSDART00000136530.2
    Conserved Domains (2) summary
    cd11720
    Location:47 → 1295
    FANCI; Fanconi anemia I protein
    pfam14674
    Location:7 → 59
    FANCI_S1-cap; FANCI solenoid 1 cap
Nucleotide Protein Strain
Heading Accession and Version

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