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seb enterotoxin B [ Staphylococcus aureus subsp. aureus COL ]

Gene ID: 3237776, discontinued on 3-Feb-2015
  • All Gene records for this genome have been discontinued due to a change in scope for prokaryotic genomes in Gene. At the time this Gene record was discontinued, the RefSeq genome was re-annotated with the following features at this location:

Summary

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Gene symbol
seb
Gene description
enterotoxin B
Locus tag
SACOL0907
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Staphylococcus aureus subsp. aureus COL (strain: COL, sub-species: aureus)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus
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Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002951.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Double mutant of staphylococcal enterotoxin B expression is associated with enhanced antitumor activity effects and decreased pyrexia.
    Title: Evaluation of a recombinant double mutant of staphylococcal enterotoxin B (SEB-H32Q/K173E) with enhanced antitumor activity effects and decreased pyrexia.
  2. Interleukin (IL)-17A production in response to enterotoxin B could contribute to the pathophysiology of toxic shock via initiation of a cytokine cascade, while the presence of multifunctional T cells may indicate a more robust pro-inflammatory response.
    Title: Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans.
  3. Enterotoxin B (SEB) exerts a priming rather than a synergistic effect on bacterial lipoprotein-induced proinflammatory cytokine release from isolated human monocytes.
    Title: Bacterial superantigens enhance the in vitro proinflammatory response and in vivo lethality of the TLR2 agonist bacterial lipoprotein.
  4. thymol subinhibitory concentrations reduce enterotoxins A and B and alpha-hemolysin production in Staphylococcus aureus isolates
    Title: Subinhibitory concentrations of thymol reduce enterotoxins A and B and alpha-hemolysin production in Staphylococcus aureus isolates.
  5. Staphylococcus aureus enterotoxin B exerts a direct pro-inflammatory effect on human nasal epithelial cells, with induction of chemokine and growth factor release, resulting in the migration and prolonged survival of granulocytes in vitro.
    Title: Staphylococcus aureus enterotoxin B augments granulocyte migration and survival via airway epithelial cell activation.
  6. SEB markedly enhanced the flare-up reaction of ear swelling induced by dinitrofluorobenzene, the proliferative response of lymph node cells and the production of IFN-gamma
    Title: Staphylococcal enterotoxin B enhances a flare-up reaction of murine contact hypersensitivity through up-regulation of interferon-gamma.
  7. there were no differences in enterotoxin genes between S. aureus strains isolated from controls compared with nasal polyposis patients.
    Title: Detection of enterotoxin DNA in Staphylococcus aureus strains obtained from the middle meatus in controls and nasal polyp patients.
  8. Effective in treaing high-risk cornea transplsantation.
    Title: SEB combined with IL-1ra could prolong the survival of the rat allografts in high-risk corneal transplantation.
  9. Repeated chronic intranasal exposure to SEB superantigen causes airway inflammation and systemic immune activation in HLA class II transgenic mice.
    Title: Intranasal exposure to bacterial superantigens induces airway inflammation in HLA class II transgenic mice.
  10. In rats challenged with SEB, spray dried porcine plasma supplementation can increase glucose absorption during the interdigestive periods.
    Title: Spray-dried porcine plasma reduces the effects of staphylococcal enterotoxin B on glucose transport in rat intestine.
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General protein information

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Names
enterotoxin B
YP_185778.1
  • identified by similarity to GP:3212819; match to protein family HMM PF01123; match to protein family HMM PF02876

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002951.2 Reference assembly

    Range
    916478..917278
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_185778.1 enterotoxin B [Staphylococcus aureus subsp. aureus COL]

    Status: PROVISIONAL

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HHH9.1

Gene LinkOut

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Research Materials