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HOXD11 homeobox D11 [ Homo sapiens (human) ]

Gene ID: 3237, updated on 13-Mar-2020

Summary

Official Symbol
HOXD11provided by HGNC
Official Full Name
homeobox D11provided by HGNC
Primary source
HGNC:HGNC:5134
See related
Ensembl:ENSG00000128713 MIM:142986
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOX4; HOX4F
Summary
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in endometrium (RPKM 10.2), colon (RPKM 4.5) and 2 other tissues See more
Orthologs

Genomic context

See HOXD11 in Genome Data Viewer
Location:
2q31.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (176107280..176109754)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (176971721..176976563)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene homeobox D12 Neighboring gene sine oculis-binding protein homolog Neighboring gene homeobox D10 Neighboring gene homeobox D9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
branching involved in ureteric bud morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
dorsal/ventral pattern formation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
homeobox protein Hox-D11
Names
Hox-4.6, mouse, homolog of
homeo box 4F
homeo box D11
homeobox protein Hox-4F

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021192.3NP_067015.2  homeobox protein Hox-D11

    See identical proteins and their annotated locations for NP_067015.2

    Status: REVIEWED

    Source sequence(s)
    AC009336
    Consensus CDS
    CCDS2265.1
    UniProtKB/Swiss-Prot
    P31277
    Related
    ENSP00000249504.5, ENST00000249504.7
    Conserved Domains (2) summary
    pfam00046
    Location:269322
    Homeobox; Homeobox domain
    pfam12045
    Location:26185
    DUF3528; Protein of unknown function (DUF3528)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    176107280..176109754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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