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HOXD11 homeobox D11 [ Homo sapiens (human) ]

Gene ID: 3237, updated on 10-Dec-2024

Summary

Official Symbol
HOXD11provided by HGNC
Official Full Name
homeobox D11provided by HGNC
Primary source
HGNC:HGNC:5134
See related
Ensembl:ENSG00000128713 MIM:142986; AllianceGenome:HGNC:5134
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOX4; HOX4F
Summary
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in endometrium (RPKM 10.2), colon (RPKM 4.5) and 2 other tissues See more
Orthologs
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Genomic context

See HOXD11 in Genome Data Viewer
Location:
2q31.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (176107280..176115679)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (176595402..176599952)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (176972008..176974482)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene homeobox D13 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:176961670-176962253 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:176962254-176962836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:176964378-176965110 Neighboring gene homeobox D12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:176968878-176969864 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:176980400-176981072 Neighboring gene homeobox D10 Neighboring gene homeobox D9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in branching involved in ureteric bud morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dorsal/ventral pattern formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in embryonic skeletal joint morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
homeobox protein Hox-D11
Names
Hox-4.6, mouse, homolog of
homeo box 4F
homeo box D11
homeobox protein Hox-4F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021192.3NP_067015.2  homeobox protein Hox-D11

    See identical proteins and their annotated locations for NP_067015.2

    Status: REVIEWED

    Source sequence(s)
    AC009336
    Consensus CDS
    CCDS2265.1
    UniProtKB/Swiss-Prot
    A6NIS4, P31277, Q9NS02
    Related
    ENSP00000249504.5, ENST00000249504.7
    Conserved Domains (2) summary
    pfam00046
    Location:269322
    Homeobox; Homeobox domain
    pfam12045
    Location:26185
    DUF3528; Protein of unknown function (DUF3528)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    176107280..176115679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007073114.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    176595402..176599952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008486353.1 RNA Sequence