U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

zbtb16a zinc finger and BTB domain containing 16a [ Danio rerio (zebrafish) ]

Gene ID: 323269, updated on 9-Sep-2025
Official Symbol
zbtb16aprovided by ZNC
Official Full Name
zinc finger and BTB domain containing 16aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1989
See related
Ensembl:ENSDARG00000007184 AllianceGenome:ZFIN:ZDB-GENE-030131-1989
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ZNF145; zbtb16; zgc:55675; wu:fb93g12; wu:fc07c10
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within positive regulation of type I interferon production and regulation of neurogenesis. Located in nucleus. Is expressed in several structures, including anterior neural keel; anterior neural rod; central nervous system; pleuroperitoneal region; and posterior neural rod. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human ZBTB16 (zinc finger and BTB domain containing 16). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See zbtb16a in Genome Data Viewer
Location:
chromosome: 21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 21 NC_133196.1 (24600815..24748855, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 21 NC_007132.7 (23163987..23307796, complement)

Chromosome 21 - NC_133196.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 28 Neighboring gene uncharacterized LOC137488814 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 3B Neighboring gene uncharacterized LOC141379868 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 3A Neighboring gene uncharacterized LOC137488815 Neighboring gene neural cell adhesion molecule 1a Neighboring gene uncharacterized LOC141379812

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. A zebrafish model for pyruvate dehydrogenase deficiency: rescue of neurological dysfunction and embryonic lethality using a ketogenic diet. Taylor MR, et al. Proc Natl Acad Sci U S A, 2004 Mar 30. PMID 15070761, Free PMC Article
  2. Evaluation of Sycp3, Plzf and Cyclin B3 expression and suitability as spermatogonia and spermatocyte markers in zebrafish. Ozaki Y, et al. Gene Expr Patterns, 2011 Jun-Jul. PMID 21402175
  3. Isolation and cytogenetic characterization of zebrafish meiotic prophase I mutants. Saito K, et al. Dev Dyn, 2011 Jul. PMID 21594953
  4. Establishment of novel monoclonal antibodies for identification of type A spermatogonia in teleosts†. Hayashi M, et al. Biol Reprod, 2019 Aug 1. PMID 31077286
  5. Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases. Dai YT, et al. Proc Natl Acad Sci U S A, 2022 Apr 12. PMID 35385357, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zbtb16 mediates a switch between Fgf signalling regimes in the developing hindbrain.
    Title: Zbtb16 mediates a switch between Fgf signalling regimes in the developing hindbrain.
  2. the results provide strong evidence that zbtb16a loss of function is associated with a partially penetrant severe cardiac development defect.
    Title: A Rapid Method for Directed Gene Knockout for Screening in G0 Zebrafish.
  3. Although zbtb16a and zbtb16b are not modulated by IFN produced during viral infection, their over-expression increases the level of the early type I IFN response, at a critical phase in the race between the virus and the host response.
    Title: Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of macromolecule biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of multicellular organismal process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of multicellular organismal development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of neurogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger and BTB domain-containing protein 16-A
Names
plzfa
promyelocytic leukemia zinc finger protein-A
zinc finger and BTB domain containing 16
zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199635.1 → NP_955929.1  zinc finger and BTB domain-containing protein 16-A

    See identical proteins and their annotated locations for NP_955929.1

    Status: PROVISIONAL

    Source sequence(s)
    BC046887
    UniProtKB/Swiss-Prot
    Q802Y8
    Related
    ENSDARP00000153802.1, ENSDART00000184419.1
    Conserved Domains (6) summary
    smart00225
    Location:35 → 106
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:445 → 620
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:546 → 566
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:515 → 537
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:25 → 106
    BTB; BTB/POZ domain
    pfam13465
    Location:559 → 582
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133196.1 Reference GRCz12tu Primary Assembly

    Range
    24600815..24748855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009295291.5 → XP_009293566.1  zinc finger and BTB domain-containing protein 16-A isoform X2

    UniProtKB/TrEMBL
    A0A8M3ATT4, E7FDS7
    Related
    ENSDARP00000024790.8
    Conserved Domains (6) summary
    smart00225
    Location:35 → 106
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:445 → 619
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:517 → 537
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:515 → 537
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:25 → 106
    BTB; BTB/POZ domain
    pfam13465
    Location:558 → 581
    zf-H2C2_2; Zinc-finger double domain

  2. XM_073934254.1 → XP_073790355.1  zinc finger and BTB domain-containing protein 16-A isoform X2

    UniProtKB/TrEMBL
    A0A8M3ATT4, E7FDS7

  3. XM_073934253.1 → XP_073790354.1  zinc finger and BTB domain-containing protein 16-A isoform X1

RNA

  1. XR_012396460.1 RNA Sequence

  2. XR_012396459.1 RNA Sequence

  3. XR_012396461.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q802Y8.1 GenPept UniProtKB/Swiss-Prot:Q802Y8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials