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Neto Neuropilin and tolloid-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32303, updated on 16-Jun-2026
Official Symbol
Netoprovided by FlyBase
Official Full Name
Neuropilin and tolloid-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0265416
Locus tag
Dmel_CG44328
See related
AllianceGenome:FB:FBgn0265416
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12727; CG15751; CG15752; CG15753; CG32635; CG44328; CT36003; Dmel\CG44328; net; neto; NETO; tld-like
Old locus tag
Dmel_CG15753; Dmel_CG32635
Summary
Involved in several processes, including hatching behavior; neuromuscular synaptic transmission; and synapse organization. Located in muscle cell postsynaptic specialization. Part of ionotropic glutamate receptor complex. Is expressed in embryonic/larval neuromuscular junction. Orthologous to human NETO1 (neuropilin and tolloid like 1) and NETO2 (neuropilin and tolloid like 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See Neto in Genome Data Viewer
Location:
11F7-12A2; 1-44 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13445903..13527282)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13339936..13421315)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene SET domain containing 2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44427 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Patterns and processes of genome-wide divergence between North American and African Drosophila melanogaster. Yukilevich R, et al. Genetics, 2010 Sep. PMID 20551441, Free PMC Article
  2. Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors. Han TH, et al. Proc Natl Acad Sci U S A, 2015 May 12. PMID 25918369, Free PMC Article
  3. The gating properties of Drosophila NMJ glutamate receptors and their dependence on Neto. Han TH, et al. J Physiol, 2024 Dec. PMID 39602131, Free PMC Article
  4. Neto-α Controls Synapse Organization and Homeostasis at the Drosophila Neuromuscular Junction. Han TH, et al. Cell Rep, 2020 Jul 7. PMID 32640231, Free PMC Article
  5. Disruption of Drosophila larval muscle structure and function by UNC45 knockdown. Karunendiran A, et al. BMC Mol Cell Biol, 2021 Jul 13. PMID 34256704, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neto-alpha Controls Synapse Organization and Homeostasis at the Drosophila Neuromuscular Junction.
    Title: Neto-α Controls Synapse Organization and Homeostasis at the Drosophila Neuromuscular Junction.
  2. only Neto-beta restored PAK synaptic accumulation at neto null NMJs. Thus, Neto engages in intracellular interactions that regulate the iGluR subtype composition by preferentially recruiting and/or stabilizing selective receptor subtypes.
    Title: Neto-mediated intracellular interactions shape postsynaptic composition at the Drosophila neuromuscular junction.
  3. neto null mutants rescued with a Neto variant that cannot be processed have severely impaired NMJs and reduced iGluRs synaptic clusters. Unprocessed Neto retains the ability to engage iGluRs in vivo and to form complexes with normal synaptic transmission
    Title: Prodomain removal enables neto to stabilize glutamate receptors at the Drosophila neuromuscular junction.
  4. these studies reveal that Drosophila Neto is a novel, essential component of the iGluR complexes and is required for iGluR clustering, organization of PSDs, and synapse functionality.
    Title: Drosophila Neto is essential for clustering glutamate receptors at the neuromuscular junction.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

mobile_element

  • Loc: 13463700-13469219 mobile_element_type = transposon:mdg3{}119
Preferred Names
neuropilin and tolloid-like
Names
CG44328-PA
CG44328-PB
Neto-PA
Neto-PB

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13445903..13527282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298282.1 → NP_001285211.1  neuropilin and tolloid-like, isoform B

    See identical proteins and their annotated locations for NP_001285211.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4LU05, X2JDL4
    Conserved Domains (2) summary
    cd00041
    Location:151 → 252
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:392 → 426
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  2. NM_167371.2 → NP_727708.1  neuropilin and tolloid-like, isoform A

    See identical proteins and their annotated locations for NP_727708.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K023, Q8SZJ8, Q9VYC7
    Related
    FBpp0308759
    Conserved Domains (2) summary
    cd00041
    Location:151 → 252
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:392 → 426
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G4LU05 G4LU05
Q9VYC7 Q9VYC7

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