U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

prom1a prominin 1a [ Danio rerio (zebrafish) ]

Gene ID: 322857, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
prom1aprovided by ZNC
Official Full Name
prominin 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1577
See related
Ensembl:ENSDARG00000039966 AllianceGenome:ZFIN:ZDB-GENE-030131-1577
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
prom1; proml1; fb75c01; wu:fb75c01
Summary
Predicted to enable cholesterol binding activity. Predicted to be located in endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; and plasma membrane. Predicted to be active in several cellular components, including apical plasma membrane; microvillus; and prominosome. Predicted to be integral component of plasma membrane. Is expressed in gill; muscle; nervous system; otic vesicle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12 and retinitis pigmentosa 41. Orthologous to human PROM1 (prominin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 14
Exon count:
31
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (46456088..46616591, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (47469007..47629506, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor binding protein 1a Neighboring gene fibroblast growth factor binding protein 2a Neighboring gene si:dkey-13a3.5 Neighboring gene transmembrane anterior posterior transformation 1a Neighboring gene LIM domain binding 2a

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Use of RecA fusion proteins to induce genomic modifications in zebrafish. Liao HK, et al. Nucleic Acids Res, 2011 May. PMID 21266475, Free PMC Article
  2. Expression of the zebrafish CD133/prominin1 genes in cellular proliferation zones in the embryonic central nervous system and sensory organs. McGrail M, et al. Dev Dyn, 2010 Jun. PMID 20503380
  3. Spatial distribution of prominin-1 (CD133)-positive cells within germinative zones of the vertebrate brain. Jászai J, et al. PLoS One, 2013. PMID 23723983, Free PMC Article
  4. Distinct and conserved prominin-1/CD133-positive retinal cell populations identified across species. Jászai J, et al. PLoS One, 2011 Mar 2. PMID 21407811, Free PMC Article
  5. Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3. Jászai J, et al. J Biol Chem, 2020 May 1. PMID 32201384, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microvillus membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in prominosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
prominin-1-A
Names
prominin-1a.s11
prominin-1a.s18
prominin-1a.s19
prominin-1a.s20
prominin-like 1
prominin-like protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001115143.2 → NP_001108615.2  prominin-1-A precursor

    See identical proteins and their annotated locations for NP_001108615.2

    Status: PROVISIONAL

    Source sequence(s)
    BC163446
    UniProtKB/Swiss-Prot
    B3DJD7, Q9W735
    Related
    ENSDART00000171702.2
    Conserved Domains (1) summary
    pfam05478
    Location:51 → 816
    Prominin; Prominin

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    46456088..46616591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480970.1 → XP_021336645.1  prominin-1-A isoform X4

    UniProtKB/TrEMBL
    A0A8M9QP21
    Conserved Domains (1) summary
    pfam05478
    Location:50 → 830
    Prominin

  2. XM_021480969.1 → XP_021336644.1  prominin-1-A isoform X3

    UniProtKB/TrEMBL
    A0A8M9QGA0
    Conserved Domains (1) summary
    pfam05478
    Location:50 → 831
    Prominin

  3. XM_021480968.1 → XP_021336643.1  prominin-1-A isoform X1

    UniProtKB/TrEMBL
    A0A8M9QAU9
    Conserved Domains (1) summary
    pfam05478
    Location:50 → 839
    Prominin

  4. XM_009291267.3 → XP_009289542.1  prominin-1-A isoform X2

    UniProtKB/TrEMBL
    A0A8M3AI42
    Conserved Domains (1) summary
    pfam05478
    Location:51 → 833
    Prominin; Prominin

  5. XM_021480975.1 → XP_021336650.1  prominin-1-A isoform X11

    UniProtKB/TrEMBL
    A0A8M9QP25
    Related
    ENSDARP00000096190.4, ENSDART00000105417.5
    Conserved Domains (1) summary
    pfam05478
    Location:50 → 839
    Prominin

  6. XM_021480972.1 → XP_021336647.1  prominin-1-A isoform X7

    UniProtKB/TrEMBL
    A0A8M9PZ24
    Conserved Domains (1) summary
    pfam05478
    Location:50 → 839
    Prominin

  7. XM_021480971.1 → XP_021336646.1  prominin-1-A isoform X5

    UniProtKB/TrEMBL
    A0A8M9QKH3
    Conserved Domains (1) summary
    pfam05478
    Location:50 → 839
    Prominin

  8. XM_009291269.3 → XP_009289544.1  prominin-1-A isoform X6

    UniProtKB/TrEMBL
    A0A8M3AS96
    Conserved Domains (1) summary
    pfam05478
    Location:51 → 816
    Prominin; Prominin

  9. XM_021480973.1 → XP_021336648.1  prominin-1-A isoform X8

    UniProtKB/TrEMBL
    A0A0R4IAM7, A0A0R4IZS3, A0A8M9QAV3
    Related
    ENSDARP00000141823.1, ENSDART00000171476.2
    Conserved Domains (1) summary
    pfam05478
    Location:50 → 822
    Prominin

  10. XM_005157351.3 → XP_005157408.1  prominin-1-A isoform X13

    UniProtKB/TrEMBL
    A0A8M2B446, H7BWW9
    Related
    ENSDARP00000096191.5, ENSDART00000105418.6
    Conserved Domains (1) summary
    pfam05478
    Location:51 → 825
    Prominin; Prominin

  11. XM_005157349.3 → XP_005157406.1  prominin-1-A isoform X12

    UniProtKB/TrEMBL
    A0A0R4IHU7, A0A8M2B468
    Related
    ENSDARP00000135195.1, ENSDART00000166550.2
    Conserved Domains (1) summary
    pfam05478
    Location:51 → 833
    Prominin; Prominin

  12. XM_005157347.3 → XP_005157404.1  prominin-1-A isoform X10

    UniProtKB/TrEMBL
    A0A0R4IE66, A0A8M2B3M9
    Related
    ENSDARP00000131037.1, ENSDART00000158144.2
    Conserved Domains (1) summary
    pfam05478
    Location:51 → 816
    Prominin; Prominin

  13. XM_021480974.1 → XP_021336649.1  prominin-1-A isoform X9

    UniProtKB/TrEMBL
    A0A8M9QGA5
    Conserved Domains (1) summary
    pfam05478
    Location:50 → 839
    Prominin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W735.2 GenPept UniProtKB/Swiss-Prot:Q9W735

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous