U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IP3K2 Inositol 1,4,5-triphosphate kinase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32285, updated on 8-Feb-2025

Summary

Go to the top of the page Help
Official Symbol
IP3K2provided by FlyBase
Official Full Name
Inositol 1,4,5-triphosphate kinase 2provided by FlyBase
Primary source
FLYBASE:FBgn0283680
Locus tag
Dmel_CG45017
See related
AllianceGenome:FB:FBgn0283680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12724; CG15745; CG1630; CG34359; CG4501; CG45017; D-IP3K2; DIP3K2; Dmel\CG45017; dmIP3K2; dmIP3Kbeta; dmIP[[3]]beta; ip3k2; IP[[3]]K-2; IP[[3]]K2; NP2758; wy
Old locus tag
CG12724; CG1630; Dmel_CG12724; Dmel_CG15745; Dmel_CG1630; Dmel_CG34359
Summary
Enables calcium-dependent protein binding activity; calmodulin binding activity; and inositol-1,4,5-trisphosphate 3-kinase activity. Involved in autophagic cell death; inositol phosphate biosynthetic process; and negative regulation of cytosolic calcium ion concentration. Located in cytoplasm. Is expressed in several structures, including Kenyon cell; dopaminergic PPL1 neuron; embryonic/larval midgut primordium; epidermis; and gut section. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to several human genes including ITPKB (inositol-trisphosphate 3-kinase B). [provided by Alliance of Genome Resources, Feb 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See IP3K2 in Genome Data Viewer
Location:
11E9-11E11; 1-42 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13303633..13329303)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13197666..13223336)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Remoulade Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45018 Neighboring gene long non-coding RNA:CR32636 Neighboring gene Peroxiredoxin 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Regulation of inositol 1,4,5-trisphosphate 3-kinases by calcium and localization in cells. Lloyd-Burton SM, et al. J Biol Chem, 2007 Mar 30. PMID 17284449
  2. Increased Levels of the Parkinson's Disease-Associated Gene ITPKB Correlate with Higher Expression Levels of α-Synuclein, Independent of Mutation Status. Di Leva F, et al. Int J Mol Sci, 2023 Jan 19. PMID 36768321, Free PMC Article
  3. Convergence of multimodal sensory pathways to the mushroom body calyx in Drosophila melanogaster. Yagi R, et al. Sci Rep, 2016 Jul 11. PMID 27404960, Free PMC Article
  4. Functional and bioinformatics analyses reveal conservation of cis-regulatory elements between sciaridae and drosophilidae. Lecci MS, et al. Genesis, 2008 Jan. PMID 18196600
  5. The wavy Mutation Maps to the Inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) Gene of Drosophila and Interacts with IP3R to Affect Wing Development. Dean DM, et al. G3 (Bethesda), 2015 Nov 27. PMID 26613949, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila miR-14 regulates context-specific autophagy through its target, inositol 1,4,5-trisphosphate kinase 2 (ip3k2).
    Title: miR-14 regulates autophagy during developmental cell death by targeting ip3-kinase 2.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol hexakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagic cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in autophagic cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
inositol 1,4,5-triphosphate kinase 2
Names
CG45017-PA
CG45017-PB
CG45017-PC
CG45017-PD
CG45017-PG
CG45017-PH
IP3K2-PA
IP3K2-PB
IP3K2-PC
IP3K2-PD
IP3K2-PG
IP3K2-PH
wavy
NP_001096969.1
NP_001285200.1
NP_001285201.1
NP_572873.2
NP_572875.1
NP_727688.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13303633..13329303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298272.1 → NP_001285201.1  inositol 1,4,5-triphosphate kinase 2, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285201.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYE7
    Conserved Domains (1) summary
    pfam03770
    Location:217 → 426
    IPK; Inositol polyphosphate kinase

  2. NM_132645.3 → NP_572873.2  inositol 1,4,5-triphosphate kinase 2, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572873.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KV26
    Conserved Domains (1) summary
    pfam03770
    Location:441 → 650
    IPK; Inositol polyphosphate kinase

  3. NM_001103499.2 → NP_001096969.1  inositol 1,4,5-triphosphate kinase 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096969.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYE7
    Conserved Domains (1) summary
    pfam03770
    Location:217 → 426
    IPK; Inositol polyphosphate kinase

  4. NM_001298271.1 → NP_001285200.1  inositol 1,4,5-triphosphate kinase 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285200.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYE7
    Conserved Domains (1) summary
    pfam03770
    Location:217 → 426
    IPK; Inositol polyphosphate kinase

  5. NM_167358.2 → NP_727688.1  inositol 1,4,5-triphosphate kinase 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727688.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXS8, Q9VYE6
    Related
    FBpp0310585
    Conserved Domains (1) summary
    pfam03770
    Location:419 → 628
    IPK; Inositol polyphosphate kinase

  6. NM_132647.2 → NP_572875.1  inositol 1,4,5-triphosphate kinase 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572875.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXS8, Q9VYE6
    Related
    FBpp0310584
    Conserved Domains (1) summary
    pfam03770
    Location:419 → 628
    IPK; Inositol polyphosphate kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KV26 Q7KV26
Q95RU3 Q95RU3
Q9VYE6 Q9VYE6
Q9VYE7 Q9VYE7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous