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HDAC4 Histone deacetylase 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32278, updated on 9-May-2019

Summary

Official Symbol
HDAC4provided by FlyBase
Official Full Name
Histone deacetylase 4provided by FlyBase
Primary source
FLYBASE:FBgn0041210
Locus tag
Dmel_CG1770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1770; dHDAC4; DHDAC4; Dmel\CG1770; dmHDA405; GC1770; HDAC; hdac4; HDAC4a

Genomic context

See HDAC4 in Genome Data Viewer
Location:
11E8-11E9; 1-42 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13262687..13285632, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13156720..13179665, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene multiple edematous wings Neighboring gene uncharacterized protein Neighboring gene comatose Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
histone acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase complex IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone deacetylase 4
Names
CG1770-PB
CG1770-PD
CG1770-PE
CG1770-PF
CG1770-PG
CG1770-PH
CG1770-PI
CG1770-PJ
HDAC4-PB
HDAC4-PD
HDAC4-PE
HDAC4-PF
HDAC4-PG
HDAC4-PH
HDAC4-PI
HDAC4-PJ
NP_001014736.2
NP_001245651.1
NP_001259507.1
NP_001259508.1
NP_001259509.1
NP_001259510.1
NP_572868.3
NP_727682.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13262687..13285632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272578.2NP_001259507.1  histone deacetylase 4, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259507.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHQ2
    Related
    FBpp0305523, FBtr0333331
    Conserved Domains (2) summary
    cd11681
    Location:8371211
    HDAC_classIIa; Histone deacetylases, class IIa
    cl23765
    Location:4387
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  2. NM_001272581.2NP_001259510.1  histone deacetylase 4, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259510.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PJM2
    Related
    FBpp0305526, FBtr0333334
    Conserved Domains (2) summary
    cd11681
    Location:7731147
    HDAC_classIIa; Histone deacetylases, class IIa
    cl23765
    Location:350
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  3. NM_132640.6NP_572868.3  histone deacetylase 4, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572868.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYF3
    Related
    FBpp0290513, FBtr0301298
    Conserved Domains (2) summary
    cd11681
    Location:8201194
    HDAC_classIIa; Histone deacetylases, class IIa
    cl23765
    Location:4397
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  4. NM_001272580.2NP_001259509.1  histone deacetylase 4, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259509.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PJM2
    Related
    FBpp0305525, FBtr0333333
    Conserved Domains (2) summary
    cd11681
    Location:7731147
    HDAC_classIIa; Histone deacetylases, class IIa
    cl23765
    Location:350
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  5. NM_001272579.2NP_001259508.1  histone deacetylase 4, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259508.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IR69
    Related
    FBpp0305524, FBtr0333332
    Conserved Domains (1) summary
    cd11681
    Location:7491123
    HDAC_classIIa; Histone deacetylases, class IIa
  6. NM_001014736.5NP_001014736.2  histone deacetylase 4, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014736.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q59E49
    Related
    FBpp0290514, FBtr0301299
    Conserved Domains (2) summary
    cd11681
    Location:7711145
    HDAC_classIIa; Histone deacetylases, class IIa
    cl23765
    Location:4397
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  7. NM_001258722.3NP_001245651.1  histone deacetylase 4, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245651.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NEF2
    Related
    FBpp0300800, FBtr0308576
    Conserved Domains (2) summary
    cd11681
    Location:8101184
    HDAC_classIIa; Histone deacetylases, class IIa
    cl23765
    Location:4386
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  8. NM_167356.3NP_727682.1  histone deacetylase 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727682.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IR69
    Related
    FBpp0073629, FBtr0073798
    Conserved Domains (1) summary
    cd11681
    Location:7491123
    HDAC_classIIa; Histone deacetylases, class IIa
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