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HOXC11 homeobox C11 [ Homo sapiens (human) ]

Gene ID: 3227, updated on 12-Oct-2019


Official Symbol
HOXC11provided by HGNC
Official Full Name
homeobox C11provided by HGNC
Primary source
See related
Ensembl:ENSG00000123388 MIM:605559
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Low expression observed in reference dataset See more

Genomic context

See HOXC11 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (53973126..53977643)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (54366910..54370203)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene HOXC13 antisense RNA Neighboring gene homeobox C13 Neighboring gene uncharacterized LOC105369775 Neighboring gene homeobox C12 Neighboring gene HOX transcript antisense RNA Neighboring gene NUP98-HOXC11 recombination region Neighboring gene HOXC11-HOXC10 intergenic CAGE-defined high expression enhancer Neighboring gene HOXC cluster antisense RNA 3 Neighboring gene homeobox C10

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Endoderm Differentiation, organism-specific biosystem (from WikiPathways)
    Endoderm Differentiation, organism-specific biosystemModel depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC4906

Gene Ontology Provided by GOA

Process Evidence Code Pubs
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
embryonic skeletal joint morphogenesis IEA
Inferred from Electronic Annotation
more info
endoderm development TAS
Traceable Author Statement
more info
metanephros development IEA
Inferred from Electronic Annotation
more info
organ induction IEA
Inferred from Electronic Annotation
more info
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
proximal/distal pattern formation IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
nucleoplasm IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
homeobox protein Hox-C11
homeo box C11
homeobox protein Hox-3H

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014212.4NP_055027.1  homeobox protein Hox-C11

    See identical proteins and their annotated locations for NP_055027.1

    Status: REVIEWED

    Source sequence(s)
    AC012531, AJ000041, BC001543
    Consensus CDS
    ENSP00000446680.1, ENST00000546378.1
    Conserved Domains (2) summary
    Homeobox; Homeobox domain
    DUF3528; Protein of unknown function (DUF3528)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)
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