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Smr Smrter [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32225, updated on 8-Feb-2025

Summary

Official Symbol
Smrprovided by FlyBase
Official Full Name
Smrterprovided by FlyBase
Primary source
FLYBASE:FBgn0265523
Locus tag
Dmel_CG4013
See related
AllianceGenome:FB:FBgn0265523
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0153538.73; CG12719; CG4013; Dmel\CG4013; E52; l(1)G0060; l(1)G0361; lincRNA.983; smr; SMR; SMRTER
Summary
Enables chromatin binding activity. Involved in several processes, including follicle cell of egg chamber development; negative regulation of transcription by RNA polymerase II; and wing disc development. Located in polytene chromosome. Part of transcription repressor complex. Is expressed in several structures, including adult brain cell body rind; adult mushroom body; adult optic lobe; eye photoreceptor cell; and spermatozoon. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to several human genes including NCOR2 (nuclear receptor corepressor 2). [provided by Alliance of Genome Resources, Feb 2025]
Orthologs
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Genomic context

See Smr in Genome Data Viewer
Location:
11B10-11B14; 1-39 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12684203..12742618, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12578236..12636651, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Tis11 zinc finger protein Neighboring gene mir-9377 stem loop Neighboring gene Scutellar Macrochaetes Regulatory Gene Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43963 Neighboring gene antisense RNA:CR45623 Neighboring gene long non-coding RNA:CR44619 Neighboring gene VSR interacting RNA Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
smrter
Names
CG4013-PD
CG4013-PE
CG4013-PF
CG4013-PG
SANT domain protein
SMRT-related ecdysone receptor interacting factor
SMRT-related ecdysone receptor-interacting factor
Smr-PD
Smr-PE
Smr-PF
Smr-PG
lethal (1) G0060
silencing mediator of retinoid and thyroid hormone receptors-related ecdysone receptor-interacting factor
smarter
NP_001259491.1
  • unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    12684203..12742618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167334.2NP_727634.2  smrter, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727634.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U4I2, Q9VYK0
    Conserved Domains (3) summary
    cd00167
    Location:10031042
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam13868
    Location:7191000
    TPH; Trichohyalin-plectin-homology domain
    pfam15784
    Location:704792
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
  2. NM_001272562.1NP_001259491.1  smrter, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259491.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGZ8, Q9U4I2
    Conserved Domains (3) summary
    cd00167
    Location:10091048
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam13868
    Location:7251006
    TPH; Trichohyalin-plectin-homology domain
    pfam15784
    Location:710798
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
  3. NM_080536.4NP_536797.3  smrter, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_536797.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U4I2, Q9VYK0
    Conserved Domains (3) summary
    cd00167
    Location:10031042
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam13868
    Location:7191000
    TPH; Trichohyalin-plectin-homology domain
    pfam15784
    Location:704792
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
  4. NM_167335.2NP_727635.2  smrter, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727635.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U4I2, Q9VYK0
    Conserved Domains (3) summary
    cd00167
    Location:10031042
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam13868
    Location:7191000
    TPH; Trichohyalin-plectin-homology domain
    pfam15784
    Location:704792
    GPS2_interact; G-protein pathway suppressor 2-interacting domain