bhmt betaine-homocysteine methyltransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bhmtprovided by ZNC
Official Full Name: betaine-homocysteine methyltransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-947
See related: Ensembl:ENSDARG00000013430 AllianceGenome:ZFIN:ZDB-GENE-030131-947
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb53h01; wu:fb63c08; wu:fj64d01; zgc:123027; hm:zehn2153
Summary: Predicted to enable betaine-homocysteine S-methyltransferase activity. Acts upstream of or within digestive system development and type B pancreatic cell development. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in hepatocyte; liver; yolk; and yolk syncytial layer. Human ortholog(s) of this gene implicated in cerebral infarction; congenital heart disease; and pulmonary embolism. Orthologous to several human genes including BHMT (betaine--homocysteine S-methyltransferase). [provided by Alliance of Genome Resources, May 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	21	NC_133196.1 (349718..354916, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (40398..45576, complement)

Chromosome 21 - NC_133196.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

function for Bhmt involving modulation of Shh signaling to control beta-cell development.
Title: Depletion of Bhmt elevates sonic hedgehog transcript level and increases β-cell number in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fb53h01.x1 (e-PCR)
- UniSTS:203314

fc58g09.y1 (e-PCR)
- UniSTS:194128

AI617817 (e-PCR)
- UniSTS:206162

fb63c08.x1 (e-PCR)
- UniSTS:203405

Z9792 (e-PCR)
- UniSTS:74202

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables betaine-homocysteine S-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables betaine-homocysteine S-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-methionine salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino-acid betaine catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within digestive system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within type B pancreatic cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: betaine--homocysteine S-methyltransferase 1

NP_001012498.2

EC 2.1.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.