vdac2 voltage-dependent anion channel 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: vdac2provided by ZNC
Official Full Name: voltage-dependent anion channel 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-845
See related: Ensembl:ENSDARG00000013623 AllianceGenome:ZFIN:ZDB-GENE-030131-845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55795; zgc:77621; wu:fa01a08; wu:fa98a10; wu:fb50g11
Summary: Enables channel activity and identical protein binding activity. Acts upstream of or within calcium import into the mitochondrion; fin regeneration; and regulation of heart contraction. Located in plasma membrane. Is expressed in several structures, including lens; pectoral fin; pericardial region; solid lens vesicle; and ventral mesoderm. Orthologous to human VDAC2 (voltage dependent anion channel 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	13	NC_133188.1 (19699741..19959371, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (17714301..17729474, complement)

Chromosome 13 - NC_133188.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings demonstrate a critical modulatory role for VDAC2-dependent mitochondrial Ca(2+) uptake in the regulation of cardiac rhythmicity.
Title: Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity.
Data indicate the structure of voltage-dependent anion channel 2 zfVDAC2 at 2.8 A resolution, revealing a crystallographic dimer.
Title: High resolution structure and double electron-electron resonance of the zebrafish voltage-dependent anion channel 2 reveal an oligomeric population.

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General gene information

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Markers

fa98a10 (e-PCR)
- UniSTS:188932

fa01a08.s1 (e-PCR)
- UniSTS:202109

fa01a08.r1 (e-PCR)
- UniSTS:186854

fb50g11.x1 (e-PCR)
- UniSTS:203257

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables channel activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables porin activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated monoatomic anion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic anion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium import into the mitochondrion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fin regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of heart contraction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of pore complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: voltage-dependent anion-selective channel protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.