gnb1a guanine nucleotide binding protein (G protein), beta polypeptide 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gnb1aprovided by ZNC
Official Full Name: guanine nucleotide binding protein (G protein), beta polypeptide 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-823
See related: Ensembl:ENSDARG00000090454 AllianceGenome:ZFIN:ZDB-GENE-030131-823
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gnb1; wu:fb50b09; wu:fj94h04
Summary: Predicted to enable signaling receptor complex adaptor activity. Acts upstream of or within positive regulation of neutrophil migration and posterior lateral line neuromast primordium migration. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including blastomere; brain; epidermis; fin; and sensory system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; autosomal dominant intellectual developmental disorder 42; congestive heart failure; and myelodysplastic syndrome. Orthologous to human GNB1 (G protein subunit beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	8	NC_133183.1 (63273224..63337598)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (53269657..53331655)

Chromosome 8 - NC_133183.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data indicate that Gbeta1 signaling controls proper neutrophil migration by activating Phosphatidylinositol 3-Kinase and modulating actin dynamics. Moreover, they illustrate a role for a specific Gbeta isoform in chemotaxis in vivo.
Title: Gβ1 is required for neutrophil migration in zebrafish.
Gbetagamma signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity.
Title: Gβγ signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity.

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General gene information

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Markers

fj09c08.y1 (e-PCR)
- UniSTS:198479

AI478004 (e-PCR)
- UniSTS:206417

fc59a01.y1 (e-PCR)
- UniSTS:194134

G39845 (e-PCR)
- UniSTS:47036

AW184123 (e-PCR)
- UniSTS:205764

fj94h04.x1 (e-PCR)
- UniSTS:200408

fb50b09.x1 (e-PCR)
- UniSTS:203248

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables signaling receptor complex adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of neutrophil migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within posterior lateral line neuromast primordium migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Names: guanine nucleotide binding protein (G protein), beta polypeptide 1; transducin beta chain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212609.1 → NP_997774.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

See identical proteins and their annotated locations for NP_997774.1

Status: PROVISIONAL

Source sequence(s)

BC056708

UniProtKB/Swiss-Prot

Q6PH57

Related

ENSDARP00000150406.1, ENSDART00000184212.1

Conserved Domains (3) summary

COG2319
Location:49 → 340

WD40; WD40 repeat [General function prediction only]

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]