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HOXB7 homeobox B7 [ Homo sapiens (human) ]

Gene ID: 3217, updated on 12-Aug-2018

Summary

Official Symbol
HOXB7provided by HGNC
Official Full Name
homeobox B7provided by HGNC
Primary source
HGNC:HGNC:5118
See related
Ensembl:ENSG00000260027 MIM:142962; Vega:OTTHUMG00000170231
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOX2; HOX2C; HHO.C1; Hox-2.3
Summary
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 10.0), colon (RPKM 8.7) and 15 other tissues See more
Orthologs

Genomic context

See HOXB7 in Genome Data Viewer
Location:
17q21.32
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (48607232..48611021, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46684594..46688383, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene HOXB cluster antisense RNA 3 Neighboring gene homeobox B5 Neighboring gene homeobox B6 Neighboring gene homeobox B8 Neighboring gene homeobox B9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
embryonic skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development NAS
Non-traceable Author Statement
more info
PubMed 
myeloid cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
homeobox protein Hox-B7
Names
homeo box 2C
homeo box B7
homeo box c1 protein
homeobox protein HHO.C1
homeobox protein Hox-2C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004502.3NP_004493.3  homeobox protein Hox-B7

    See identical proteins and their annotated locations for NP_004493.3

    Status: REVIEWED

    Source sequence(s)
    BG118354, BM923808, BP342702, BQ233410
    Consensus CDS
    CCDS11532.1
    UniProtKB/Swiss-Prot
    P09629
    Related
    ENSP00000239165.7, OTTHUMP00000216944, ENST00000239165.8, OTTHUMT00000358097
    Conserved Domains (1) summary
    pfam00046
    Location:141193
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    48607232..48611021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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