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HOXB6 homeobox B6 [ Homo sapiens (human) ]

Gene ID: 3216, updated on 7-Dec-2018

Summary

Official Symbol
HOXB6provided by HGNC
Official Full Name
homeobox B6provided by HGNC
Primary source
HGNC:HGNC:5117
See related
Ensembl:ENSG00000108511 MIM:142961
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOX2; HU-2; HOX2B; Hox-2.2
Summary
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. [provided by RefSeq, Jul 2008]
Expression
Biased expression in kidney (RPKM 11.8), colon (RPKM 5.2) and 9 other tissues See more
Orthologs

Genomic context

See HOXB6 in Genome Data Viewer
Location:
17q21.32
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (48595736..48604992, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46673099..46682343, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene homeobox B3 Neighboring gene microRNA 10a Neighboring gene HOXB cluster antisense RNA 3 Neighboring gene homeobox B5 Neighboring gene homeobox B7 Neighboring gene homeobox B8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
embryonic skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
erythrocyte homeostasis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
homeobox protein Hox-B6
Names
homeo box 2B
homeo box B6
homeobox protein Hox-2.2
homeobox protein Hox-2B
homeobox protein Hu-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046953.1 RefSeqGene

    Range
    5021..14256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018952.5NP_061825.2  homeobox protein Hox-B6

    See identical proteins and their annotated locations for NP_061825.2

    Status: REVIEWED

    Source sequence(s)
    AC103702, AI352188, AJ270993, BC014651
    Consensus CDS
    CCDS11531.1
    UniProtKB/Swiss-Prot
    P17509
    Related
    ENSP00000225648.3, ENST00000225648.3
    Conserved Domains (1) summary
    pfam00046
    Location:150202
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    48595736..48604992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257284.3XP_005257341.1  homeobox protein Hox-B6 isoform X2

    See identical proteins and their annotated locations for XP_005257341.1

    UniProtKB/Swiss-Prot
    P17509
    Related
    ENSP00000420009.2, ENST00000484302.3
    Conserved Domains (1) summary
    pfam00046
    Location:150202
    Homeobox; Homeobox domain
  2. XM_011524727.3XP_011523029.1  homeobox protein Hox-B6 isoform X1

    Conserved Domains (1) summary
    pfam00046
    Location:214266
    Homeobox; Homeobox domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_156036.1: Suppressed sequence

    Description
    NM_156036.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_156037.1: Suppressed sequence

    Description
    NM_156037.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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