cd63 CD63 molecule [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cd63provided by ZNC
Official Full Name: CD63 moleculeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-180
See related: Ensembl:ENSDARG00000025147 AllianceGenome:ZFIN:ZDB-GENE-030131-180
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cd163; zgc:65825; zgc:77709; wu:fb16b08
Summary: Acts upstream of or within hatching. Predicted to be located in several cellular components, including cell surface; cytoplasmic vesicle; and lysosomal membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including anterior axial hypoblast; dorsal fin; hatching gland; intermediate mesenchyme; and pronephric duct. Orthologous to human CD63 (CD63 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (32066294..32085939)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (32139763..32159408)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glial cells expressing visual cycle genes are vital for photoreceptor survival in the zebrafish pineal gland.
Title: Glial cells expressing visual cycle genes are vital for photoreceptor survival in the zebrafish pineal gland.
Generation of cd63-deficient zebrafish to analyze the role of cd63 in viral infection.
Title: Generation of cd63-deficient zebrafish to analyze the role of cd63 in viral infection.

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General gene information

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Markers

fj09e02.y1 (e-PCR)
- UniSTS:198485

AI397084 (e-PCR)
- UniSTS:205667

fc17c03 (e-PCR), detects polymorphism
- UniSTS:189128

fb16b08.x1 (e-PCR)
- UniSTS:202960

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within hatching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of vascular endothelial growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in multivesicular body	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CD63 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199543.1 → NP_955837.1 CD63 antigen

See identical proteins and their annotated locations for NP_955837.1

Status: PROVISIONAL

Source sequence(s)

BC056698

UniProtKB/TrEMBL

Q6P2T9, Q6PH66

Related

ENSDARP00000031764.6, ENSDART00000031047.7

Conserved Domains (2) summary

cd03166
Location:103 → 202

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:9 → 230

Tetraspannin; Tetraspanin family