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HOXB4 homeobox B4 [ Homo sapiens (human) ]

Gene ID: 3214, updated on 23-Nov-2023


Official Symbol
HOXB4provided by HGNC
Official Full Name
homeobox B4provided by HGNC
Primary source
See related
Ensembl:ENSG00000182742 MIM:142965; AllianceGenome:HGNC:5115
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOX2; HOX2F; HOX-2.6
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008]
Broad expression in fat (RPKM 4.1), lung (RPKM 2.6) and 19 other tissues See more
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Genomic context

See HOXB4 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (48575507..48578350, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (49439096..49441939, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46652869..46655712, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene HOXB cluster antisense RNA 1 Neighboring gene homeobox B2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46629432-46630177 Neighboring gene homeobox B3 Neighboring gene HOXB cluster antisense RNA 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46641715-46642519 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:46647249-46648100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46659314-46660126 Neighboring gene HOXB associated long intergenic non-coding RNA Neighboring gene microRNA 10a

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
part_of chromatin ISA
Inferred from Sequence Alignment
more info
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
located_in nucleoplasm IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
homeobox protein Hox-B4
homeo box 2F
homeo box B4
homeobox protein Hox-2.6
homeobox protein Hox-2F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024015.5NP_076920.1  homeobox protein Hox-B4

    See identical proteins and their annotated locations for NP_076920.1

    Status: REVIEWED

    Source sequence(s)
    AC103702, AL137449, BC049204
    Consensus CDS
    P17483, Q9NTA0
    ENSP00000328928.5, ENST00000332503.6
    Conserved Domains (1) summary
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    48575507..48578350 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060941.1 Alternate T2T-CHM13v2.0

    49439096..49441939 complement
    GenBank, FASTA, Sequence Viewer (Graphics)