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HOXB3 homeobox B3 [ Homo sapiens (human) ]

Gene ID: 3213, updated on 17-Jun-2019

Summary

Official Symbol
HOXB3provided by HGNC
Official Full Name
homeobox B3provided by HGNC
Primary source
HGNC:HGNC:5114
See related
Ensembl:ENSG00000120093 MIM:142966
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOX2; HOX2G; Hox-2.7
Summary
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 1.6), fat (RPKM 1.3) and 21 other tissues See more
Orthologs

Genomic context

See HOXB3 in Genome Data Viewer
Location:
17q21.32
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (48548870..48590272, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46626232..46667634, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4554 Neighboring gene HOXB cluster antisense RNA 1 Neighboring gene homeobox B2 Neighboring gene homeobox B4 Neighboring gene microRNA 10a Neighboring gene HOXB cluster antisense RNA 3 Neighboring gene homeobox B5 Neighboring gene homeobox B6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of homeobox B3 (HOXB3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
angiogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cartilage development IEA
Inferred from Electronic Annotation
more info
 
definitive hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
embryonic skeletal system morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
face development IEA
Inferred from Electronic Annotation
more info
 
glossopharyngeal nerve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
 
rhombomere development IEA
Inferred from Electronic Annotation
more info
 
thyroid gland development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
homeobox protein Hox-B3
Names
homeo box 2G
homeobox protein Hox-2.7
homeobox protein Hox-2G

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330322.2NP_001317251.1  homeobox protein Hox-B3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK299265, AK316245, CN430280, CN430281
    Consensus CDS
    CCDS82154.1
    UniProtKB/Swiss-Prot
    P14651
    Related
    ENSP00000418729.1, ENST00000489475.5
  2. NM_001330323.1NP_001317252.1  homeobox protein Hox-B3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK299226, AK316245, CN430280, CN430281, DA748374
    Consensus CDS
    CCDS82153.1
    UniProtKB/Swiss-Prot
    P14651
    Related
    ENSP00000418035.1, ENST00000460160.5
    Conserved Domains (2) summary
    pfam00046
    Location:60112
    Homeobox; Homeobox domain
    pfam13293
    Location:234297
    DUF4074; Domain of unknown function (DUF4074)
  3. NM_002146.4NP_002137.4  homeobox protein Hox-B3 isoform 1

    See identical proteins and their annotated locations for NP_002137.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC103702, AI633956, AK027609, CN358294, DA735249, X16667
    Consensus CDS
    CCDS11528.1
    UniProtKB/Swiss-Prot
    P14651
    UniProtKB/TrEMBL
    B3KNJ7
    Related
    ENSP00000308252.4, ENST00000311626.8
    Conserved Domains (2) summary
    pfam00046
    Location:192244
    Homeobox; Homeobox domain
    pfam13293
    Location:366429
    DUF4074; Domain of unknown function (DUF4074)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    48548870..48590272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257277.3XP_005257334.1  homeobox protein Hox-B3 isoform X3

    See identical proteins and their annotated locations for XP_005257334.1

    UniProtKB/Swiss-Prot
    P14651
    Related
    ENSP00000420595.1, ENST00000498678.5
    Conserved Domains (2) summary
    pfam00046
    Location:192244
    Homeobox; Homeobox domain
    pfam13293
    Location:366429
    DUF4074; Domain of unknown function (DUF4074)
  2. XM_017024560.1XP_016880049.1  homeobox protein Hox-B3 isoform X1

    Conserved Domains (2) summary
    pfam00046
    Location:339391
    Homeobox; Homeobox domain
    pfam13293
    Location:513576
    DUF4074; Domain of unknown function (DUF4074)
  3. XM_011524710.2XP_011523012.1  homeobox protein Hox-B3 isoform X3

    See identical proteins and their annotated locations for XP_011523012.1

    UniProtKB/Swiss-Prot
    P14651
    Conserved Domains (2) summary
    pfam00046
    Location:192244
    Homeobox; Homeobox domain
    pfam13293
    Location:366429
    DUF4074; Domain of unknown function (DUF4074)
  4. XM_006721854.3XP_006721917.1  homeobox protein Hox-B3 isoform X3

    See identical proteins and their annotated locations for XP_006721917.1

    UniProtKB/Swiss-Prot
    P14651
    Conserved Domains (2) summary
    pfam00046
    Location:192244
    Homeobox; Homeobox domain
    pfam13293
    Location:366429
    DUF4074; Domain of unknown function (DUF4074)
  5. XM_011524721.3XP_011523023.1  homeobox protein Hox-B3 isoform X4

    Conserved Domains (2) summary
    pfam00046
    Location:191243
    Homeobox; Homeobox domain
    pfam13293
    Location:365428
    DUF4074; Domain of unknown function (DUF4074)
  6. XM_024450737.1XP_024306505.1  homeobox protein Hox-B3 isoform X3

    Related
    ENSP00000417207.1, ENST00000470495.1
  7. XM_011524720.3XP_011523022.1  homeobox protein Hox-B3 isoform X3

    See identical proteins and their annotated locations for XP_011523022.1

    UniProtKB/Swiss-Prot
    P14651
    Conserved Domains (2) summary
    pfam00046
    Location:192244
    Homeobox; Homeobox domain
    pfam13293
    Location:366429
    DUF4074; Domain of unknown function (DUF4074)
  8. XM_011524708.3XP_011523010.2  homeobox protein Hox-B3 isoform X2

    Conserved Domains (2) summary
    pfam00046
    Location:60112
    Homeobox; Homeobox domain
    pfam13293
    Location:234297
    DUF4074; Domain of unknown function (DUF4074)
  9. XM_011524719.2XP_011523021.1  homeobox protein Hox-B3 isoform X3

    See identical proteins and their annotated locations for XP_011523021.1

    UniProtKB/Swiss-Prot
    P14651
    Conserved Domains (2) summary
    pfam00046
    Location:192244
    Homeobox; Homeobox domain
    pfam13293
    Location:366429
    DUF4074; Domain of unknown function (DUF4074)
  10. XM_011524726.2XP_011523028.1  homeobox protein Hox-B3 isoform X5

    See identical proteins and their annotated locations for XP_011523028.1

    UniProtKB/Swiss-Prot
    P14651
    Related
    ENSP00000419676.1, ENST00000472863.5
    Conserved Domains (2) summary
    pfam00046
    Location:119171
    Homeobox; Homeobox domain
    pfam13293
    Location:293356
    DUF4074; Domain of unknown function (DUF4074)
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