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noc3l NOC3-like DNA replication regulator [ Danio rerio (zebrafish) ]

Gene ID: 321289, updated on 4-Jan-2025

Summary

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Official Symbol
noc3lprovided by ZNC
Official Full Name
NOC3-like DNA replication regulatorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9878
See related
Ensembl:ENSDARG00000002487 AllianceGenome:ZFIN:ZDB-GENE-030131-9878
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
AD24; cb522; sb:cb522; c10orf117
Summary
Predicted to enable chromatin binding activity. Acts upstream of or within muscle organ development and regulation of lipid metabolic process. Located in nucleus. Is expressed in several structures, including alar plate midbrain region; brain; head; immature eye; and trunk. Orthologous to human NOC3L (NOC3 like DNA replication regulator). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See noc3l in Genome Data Viewer
Location:
chromosome: 12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (5399680..5418338, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (5364723..5383381, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene leucine-rich, glioma inactivated 1b Neighboring gene solute carrier family 35 member G1 Neighboring gene phospholipase C, epsilon 1 Neighboring gene TBC1 domain family, member 12b Neighboring gene dopamine receptor D6b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish Fad24. Walters KB, et al. Dev Dyn, 2009 Jan. PMID 19097072, Free PMC Article
  2. Single-cell analyses identify distinct and intermediate states of zebrafish pancreatic islet development. Lu CJ, et al. J Mol Cell Biol, 2019 Jun 1. PMID 30407522, Free PMC Article
  3. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278
  4. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nucleolar complex protein 3 homolog
Names
NOC3 protein homolog
NOC3-like protein
fad24
nucleolar complex associated 3 homolog
nucleolar complex-associated protein 3-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002863.1 → NP_001002863.1  nucleolar complex protein 3 homolog

    See identical proteins and their annotated locations for NP_001002863.1

    Status: PROVISIONAL

    Source sequence(s)
    AY648726
    UniProtKB/Swiss-Prot
    Q6DC88, Q6DRN3
    Related
    ENSDARP00000004350.8, ENSDART00000028043.9
    Conserved Domains (3) summary
    COG5117
    Location:121 → 713
    NOC3; Protein involved in the nuclear export of pre-ribosomes [Translation, ribosomal structure and biogenesis / Intracellular trafficking and secretion]
    pfam03914
    Location:555 → 708
    CBF; CBF/Mak21 family
    pfam07540
    Location:214 → 308
    NOC3p; Nucleolar complex-associated protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    5399680..5418338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DRN3.1 GenPept UniProtKB/Swiss-Prot:Q6DRN3

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