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ftsj3 FtsJ RNA 2'-O-methyltransferase 3 [ Danio rerio (zebrafish) ]

Gene ID: 321247, updated on 9-Sep-2025
Official Symbol
ftsj3provided by ZNC
Official Full Name
FtsJ RNA 2'-O-methyltransferase 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9828
See related
Ensembl:ENSDARG00000104938 AllianceGenome:ZFIN:ZDB-GENE-030131-9828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ftsj; cb410; sb:cb410; wu:fa08a09
Summary
Predicted to enable rRNA (guanine) methyltransferase activity and rRNA (uridine-2'-O-)-methyltransferase activity. Predicted to be involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and rRNA methylation. Predicted to act upstream of or within RNA methylation and rRNA processing. Predicted to be located in nucleus. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in several structures, including digestive system; immature eye; mesoderm; midbrain; and musculature system. Orthologous to human FTSJ3 (FtsJ RNA 2'-O-methyltransferase 3). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See ftsj3 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 22 NC_133197.1 (3308337..3337722)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 22 NC_007133.7 (3184500..3211978)

Chromosome 22 - NC_133197.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36 Neighboring gene lon peptidase 1, mitochondrial Neighboring gene lens intrinsic membrane protein 2.2 Neighboring gene G protein-coupled receptor 35, tandem duplicate 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (guanine) methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (uridine-2'-O-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within rRNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of preribosome, small subunit precursor IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
Names
FtsJ RNA methyltransferase homolog 3
FtsJ homolog 3
NP_001292397.1
XP_073792389.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305468.1 → NP_001292397.1  pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

    Status: VALIDATED

    Source sequence(s)
    CT583766, CT635598, EB793829, JBMGRA010000022
    UniProtKB/TrEMBL
    A0A0R4IQB8, A0A8M1P1T0
    Related
    ENSDARP00000136961.1, ENSDART00000160604.2
    Conserved Domains (3) summary
    COG0293
    Location:4 → 203
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]
    pfam07780
    Location:624 → 819
    Spb1_C; Spb1 C-terminal domain
    pfam11861
    Location:233 → 377
    DUF3381; Domain of unknown function (DUF3381)

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133197.1 Reference GRCz12tu Primary Assembly

    Range
    3308337..3337722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073936288.1 → XP_073792389.1  pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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