U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

apobb.1 apolipoprotein Bb, tandem duplicate 1 [ Danio rerio (zebrafish) ]

Gene ID: 321166, updated on 9-Sep-2025
Official Symbol
apobb.1provided by ZNC
Official Full Name
apolipoprotein Bb, tandem duplicate 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9732
See related
Ensembl:ENSDARG00000022767 AllianceGenome:ZFIN:ZDB-GENE-030131-9732
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
apobb; apobl; cb235; zeh1207; sb:cb235; hm:zeh1207; wu:fb39c11; wu:fc51e12; si:ch211-219i10.1
Summary
Predicted to enable cholesterol transfer activity and low-density lipoprotein particle receptor binding activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be located in extracellular region. Predicted to be part of low-density lipoprotein particle; mature chylomicron; and very-low-density lipoprotein particle. Is expressed in intestine; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table
See apobb.1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 20 NC_133195.1 (34057155..34072385)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 20 NC_007131.7 (31269724..31284893)

Chromosome 20 - NC_133195.1Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase family A, member 6 Neighboring gene hippocalcin-like 1 Neighboring gene uncharacterized LOC141379313 Neighboring gene solute carrier family 22 member 16 Neighboring gene uronyl 2-sulfotransferase a Neighboring gene uncharacterized LOC137488589

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. The LipoGlo reporter system for sensitive and specific monitoring of atherogenic lipoproteins. Thierer JH, et al. Nat Commun, 2019 Jul 31. PMID 31366908, Free PMC Article
  2. Core fucosylation is required for midline patterning during zebrafish development. Seth A, et al. Dev Dyn, 2010 Dec. PMID 21069830, Free PMC Article
  3. Development of a convenient in vivo hepatotoxin assay using a transgenic zebrafish line with liver-specific DsRed expression. Zhang X, et al. PLoS One, 2014. PMID 24626481, Free PMC Article
  4. Zebrafish mutants provide insights into Apolipoprotein B functions during embryonic development and pathological conditions. Templehof H, et al. JCI Insight, 2021 Jul 8. PMID 34236046, Free PMC Article
  5. Dynamic transcriptomic profiles of zebrafish gills in response to zinc depletion. Zheng D, et al. BMC Genomics, 2010 Oct 8. PMID 20932299, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cholesterol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables low-density lipoprotein particle receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in lipoprotein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride mobilization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of low-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mature chylomicron IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of very-low-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
apolipoprotein Bb, tandem duplicate 1
Names
apolipoprotein B, like

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030062.1 → NP_001025233.1  apolipoprotein Bb, tandem duplicate 1 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JBMGRA010000020
    UniProtKB/TrEMBL
    A0A8M1N7D8, Q5TZ29
    Related
    ENSDARP00000119179.1, ENSDART00000133353.2
    Conserved Domains (4) summary
    pfam01347
    Location:23 → 570
    Vitellogenin_N; Lipoprotein amino terminal region
    pfam06160
    Location:1912 → 2303
    EzrA; Septation ring formation regulator, EzrA
    pfam06448
    Location:925 → 1007
    DUF1081; Domain of Unknown Function (DUF1081)
    pfam09172
    Location:604 → 903
    DUF1943; Domain of unknown function (DUF1943)

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133195.1 Reference GRCz12tu Primary Assembly

    Range
    34057155..34072385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160629.4 → XP_005160686.1  apolipoprotein Bb, tandem duplicate 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B7H0
    Conserved Domains (4) summary
    pfam01347
    Location:32 → 579
    Vitellogenin_N; Lipoprotein amino terminal region
    pfam06160
    Location:1921 → 2312
    EzrA; Septation ring formation regulator, EzrA
    pfam06448
    Location:934 → 1016
    DUF1081; Domain of Unknown Function (DUF1081)
    pfam09172
    Location:613 → 912
    DUF1943; Domain of unknown function (DUF1943)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools