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ap2m1a adaptor related protein complex 2 subunit mu 1a [ Danio rerio (zebrafish) ]

Gene ID: 321051, updated on 15-Jul-2026
Official Symbol
ap2m1aprovided by ZNC
Official Full Name
adaptor related protein complex 2 subunit mu 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9784
See related
Ensembl:ENSDARG00000002790 AllianceGenome:ZFIN:ZDB-GENE-030131-9784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb34; Ap2m1; dpy-23; sb:cb34; zgc:55711; zgc:85653; wu:fa97a10
Summary
Predicted to enable clathrin adaptor activity. Acts upstream of or within Wnt signaling pathway. Predicted to be located in clathrin-coated pit and plasma membrane. Predicted to be part of AP-2 adaptor complex. Predicted to be active in cytoplasmic vesicle. Is expressed in blood; mesoderm; notochord; sensory system; and solid lens vesicle. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 60 with seizures. Orthologous to human AP2M1 (adaptor related protein complex 2 subunit mu 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See ap2m1a in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 2 NC_133177.1 (10138833..10168484, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 2 NC_007113.7 (9789820..9818673, complement)

Chromosome 2 - NC_133177.1Genomic Context describing neighboring genes Neighboring gene si:ch1073-170o4.1 Neighboring gene small nucleolar RNA SNORA13 Neighboring gene phosphate cytidylyltransferase 1A, choline a Neighboring gene annexin A13, like Neighboring gene si:ch211-252f13.5 Neighboring gene uncharacterized LOC141377752

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. AP2M1 Amplification Orchestrates Notch-Mediated Chemoresistance in Hematopoietic Stem Cells of Acute Myeloid Leukemia Patients. Lee H, et al. Adv Sci (Weinh), 2025 Dec. PMID 41082341, Free PMC Article
  2. Identification and functional characterization of AP-2 complex subunit mu-A as a new member of antimicrobial protein. Gong Y, et al. Dev Comp Immunol, 2021 Aug. PMID 33848529
  3. In vivo analysis of formation and endocytosis of the Wnt/β-catenin signaling complex in zebrafish embryos. Hagemann AI, et al. J Cell Sci, 2014 Sep 15. PMID 25074807, Free PMC Article
  4. The role of AP2M1 in oncofetal characteristics: integrative in silico, in vitro, and in vivo analyses using zebrafish models. Ahn S, et al. Eur J Med Res, 2025 Dec 1. PMID 41327404, Free PMC Article
  5. A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect. Hsu CH, et al. Sci Rep, 2015 Jun 3. PMID 26039894, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification and functional characterization of AP-2 complex subunit mu-A as a new member of antimicrobial protein.
    Title: Identification and functional characterization of AP-2 complex subunit mu-A as a new member of antimicrobial protein.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables clathrin-cargo adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-2 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
AP-2 complex subunit mu-A
Names
AP-2 complex subunit mu-1-A
AP-2 mu-2 chain A
AP-2 mu-A chain
adaptor protein complex AP-2, mu1
adaptor-related protein complex 2, mu 1 subunit, a
clathrin assembly protein complex 2 medium chain A
clathrin assembly protein complex 2 mu-A medium chain
clathrin coat assembly protein AP50-A
clathrin coat-associated protein AP50-A
mu2-adaptin-A
plasma membrane adaptor AP-2 50 kDa protein A

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291355.1 → NP_001278284.1  AP-2 complex subunit mu-A isoform 1

    See identical proteins and their annotated locations for NP_001278284.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    EB766597, EH432280, EH456153, JBMGRA010000002
    UniProtKB/Swiss-Prot
    Q7ZW98
    UniProtKB/TrEMBL
    A0A8M1P618, F1Q9V1
    Related
    ENSDARP00000106819.2, ENSDART00000124051.3
    Conserved Domains (1) summary
    cd09251
    Location:168 → 440
    AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2

  2. NM_212577.2 → NP_997742.1  AP-2 complex subunit mu-A isoform 2

    See identical proteins and their annotated locations for NP_997742.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    EB766597, EH432280, EH494715, JBMGRA010000002
    UniProtKB/Swiss-Prot
    Q6NWK2, Q7ZW98, Q802V9
    Related
    ENSDARP00000046586.5, ENSDART00000046587.7
    Conserved Domains (2) summary
    cd09251
    Location:168 → 435
    AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
    cd14836
    Location:1 → 139
    AP2_Mu_N; AP-2 complex subunit mu N-terminal domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133177.1 Reference GRCz12tu Primary Assembly

    Range
    10138833..10168484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073912098.1 → XP_073768199.1  AP-2 complex subunit mu-A isoform X1

    UniProtKB/Swiss-Prot
    Q7ZW98
    UniProtKB/TrEMBL
    A0AC58GEN7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NWK2.1 GenPept UniProtKB/Swiss-Prot:Q6NWK2

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