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Itgb8 integrin beta 8 [ Mus musculus (house mouse) ]

Gene ID: 320910, updated on 6-Jul-2021

Summary

Official Symbol
Itgb8provided by MGI
Official Full Name
integrin beta 8provided by MGI
Primary source
MGI:MGI:1338035
See related
Ensembl:ENSMUSG00000025321
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4832412O06Rik
Expression
Biased expression in kidney adult (RPKM 9.7), CNS E11.5 (RPKM 3.6) and 9 other tissues See more
Orthologs
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Genomic context

See Itgb8 in Genome Data Viewer
Location:
12; 12 F2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (119121921..119202891, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (119162803..119238276, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (120401276..120476749, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 5 Neighboring gene acyl-Coenzyme A binding domain containing 5 pseudogene Neighboring gene predicted gene, 52023 Neighboring gene nuclear receptor coactivator 4, pseudogene Neighboring gene predicted gene, 39562

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix protein binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Langerhans cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cartilage development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ganglioside metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hard palate development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transforming growth factor beta activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to virus IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
part_of integrin alphav-beta8 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin alphav-beta8 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177290.3NP_796264.2  integrin beta-8 precursor

    See identical proteins and their annotated locations for NP_796264.2

    Status: PROVISIONAL

    Source sequence(s)
    BC120691
    Consensus CDS
    CCDS36580.1
    UniProtKB/TrEMBL
    Q0VBD0
    Related
    ENSMUSP00000026360.9, ENSMUST00000026360.9
    Conserved Domains (1) summary
    smart00187
    Location:54469
    INB; Integrin beta subunits (N-terminal portion of extracellular region)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    119121921..119202891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157503.1XP_036013396.1  integrin beta-8 isoform X1

    Conserved Domains (2) summary
    NF033759
    Location:335507
    exchanger_TraA; outer membrane exchange protein TraA
    cl00057
    Location:1334
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
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