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HOXA13 homeobox A13 [ Homo sapiens (human) ]

Gene ID: 3209, updated on 13-Mar-2020

Summary

Official Symbol
HOXA13provided by HGNC
Official Full Name
homeobox A13provided by HGNC
Primary source
HGNC:HGNC:5102
See related
Ensembl:ENSG00000106031 MIM:142959
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOX1; HOX1J
Summary
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 14.7), placenta (RPKM 10.9) and 2 other tissues See more
Orthologs

Genomic context

See HOXA13 in Genome Data Viewer
Location:
7p15.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (27194364..27200091, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27236499..27239725, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene NUP98-HOXA11 recombination region Neighboring gene homeobox A11 Neighboring gene HOXA11 antisense RNA Neighboring gene NUP98-HOXA13 recombination region Neighboring gene HOXA distal transcript antisense RNA Neighboring gene EVX1 antisense RNA Neighboring gene even-skipped homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat specifically associates with HOXA13 promoter to upregulate HOXA13 expression in T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
homeobox protein Hox-A13
Names
homeo box 1J
homeo box A13
homeobox protein HOXA13
homeobox protein Hox-1J
transcription factor HOXA13

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008181.2 RefSeqGene

    Range
    5016..10743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000522.5NP_000513.2  homeobox protein Hox-A13

    See identical proteins and their annotated locations for NP_000513.2

    Status: REVIEWED

    Source sequence(s)
    AC004080, BC075791
    Consensus CDS
    CCDS5412.1
    UniProtKB/Swiss-Prot
    P31271
    UniProtKB/TrEMBL
    Q6DI00
    Related
    ENSP00000497112.1, ENST00000649031.1
    Conserved Domains (2) summary
    smart00389
    Location:322378
    HOX; Homeodomain
    pfam12284
    Location:85222
    HoxA13_N; Hox protein A13 N terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    27194364..27200091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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