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Atad2b ATPase family, AAA domain containing 2B [ Mus musculus (house mouse) ]

Gene ID: 320817, updated on 12-Apr-2023

Summary

Official Symbol
Atad2bprovided by MGI
Official Full Name
ATPase family, AAA domain containing 2Bprovided by MGI
Primary source
MGI:MGI:2444798
See related
Ensembl:ENSMUSG00000052812 AllianceGenome:MGI:2444798
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110014E10Rik; D530031C13Rik
Summary
Predicted to enable ATP hydrolysis activity; chromatin binding activity; and lysine-acetylated histone binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human ATAD2B (ATPase family AAA domain containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.7), CNS E14 (RPKM 4.6) and 28 other tissues See more
Orthologs
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Genomic context

See Atad2b in Genome Data Viewer
Location:
12; 12 A1.1
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (4964404..5097396)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (4914404..5047396)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene MFSD2 lysolipid transporter B, sphingolipid Neighboring gene UBX domain protein 2A Neighboring gene predicted gene, 23167 Neighboring gene RAB11B, member RAS oncogene family pseudogene Neighboring gene kelch-like 29 Neighboring gene VISTA enhancer mm1338

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Targeted (2) 
  • Endonuclease-mediated (2) 

General gene information

Markers

Clone Names

  • KIAA1240

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATPase family AAA domain-containing protein 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362349.1NP_001349278.1  ATPase family AAA domain-containing protein 2B

    Status: VALIDATED

    Source sequence(s)
    AC131767, CT571254
    Related
    ENSMUSP00000047445.6, ENSMUST00000045664.7
    Conserved Domains (2) summary
    cd05528
    Location:9591070
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    cl27568
    Location:396668
    TIP49; TIP49 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    4964404..5097396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515117.4XP_006515180.1  ATPase family AAA domain-containing protein 2B isoform X2

    Conserved Domains (3) summary
    cd05528
    Location:9591065
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    TIGR01243
    Location:396668
    CDC48; AAA family ATPase, CDC48 subfamily
    cl38936
    Location:768872
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_006515116.4XP_006515179.1  ATPase family AAA domain-containing protein 2B isoform X1

    Conserved Domains (4) summary
    cd05528
    Location:9581069
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    COG5076
    Location:8391084
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    TIGR01243
    Location:395667
    CDC48; AAA family ATPase, CDC48 subfamily
    cl38936
    Location:767871
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_030246779.1XP_030102639.1  ATPase family AAA domain-containing protein 2B isoform X3

    Conserved Domains (3) summary
    cd05528
    Location:304415
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    COG0464
    Location:110252
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    COG5076
    Location:185395
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
  4. XM_017315117.1XP_017170606.1  ATPase family AAA domain-containing protein 2B isoform X4

    Conserved Domains (2) summary
    cd05528
    Location:304410
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    COG0464
    Location:110252
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  5. XM_036157502.1XP_036013395.1  ATPase family AAA domain-containing protein 2B isoform X3

    Conserved Domains (3) summary
    cd05528
    Location:304415
    Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
    COG0464
    Location:110252
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    COG5076
    Location:185395
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

RNA

  1. XR_004937520.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099628.1: Suppressed sequence

    Description
    NM_001099628.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
  2. NM_177269.2: Suppressed sequence

    Description
    NM_177269.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.