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dsh dishevelled [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32078, updated on 26-Aug-2021

Summary

Official Symbol
dshprovided by FlyBase
Official Full Name
dishevelledprovided by FlyBase
Primary source
FLYBASE:FBgn0000499
Locus tag
Dmel_CG18361
Gene type
protein coding
RNA name
dishevelled
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1720; CG18361; Dm Dsh; Dmel\CG18361; Dsh; DSH; Dvl; DVL1-3; l(1)10Bd; l(1)dsh; l(1)G0267; l(1)G17
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Genomic context

See dsh in Genome Data Viewer
Location:
10B4-10B5; 1-34 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11355881..11358724)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11249914..11252757)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene PTIP associated 1 Neighboring gene hopscotch

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor complex adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor complex adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epidermis morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of epithelial cell planar polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of imaginal disc-derived wing hair orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of mitotic spindle orientation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of ommatidial planar polarity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in establishment of ommatidial planar polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of planar polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in female gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germ-line stem-cell niche homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived wing hair organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in imaginal disc-derived wing hair organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived wing margin morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ovarian follicle cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ovarian follicle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of axon extension IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of actin filament bundle assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of compound eye pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of tube length, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retinal ganglion cell axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in segment polarity determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic target inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wing and notum subfield formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Wnt signalosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dishevelled
Names
CG18361-PA
disheveled
disshevelled
dsh-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11355881..11358724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078563.3NP_511118.2  dishevelled [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511118.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P51140
    Related
    FBpp0073310, FBtr0073454
    Conserved Domains (4) summary
    smart00021
    Location:891
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:250337
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:395478
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:166248
    Dishevelled; Dishevelled specific domain
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