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Mdga2 MAM domain containing glycosylphosphatidylinositol anchor 2 [ Mus musculus (house mouse) ]

Gene ID: 320772, updated on 6-Nov-2018

Summary

Official Symbol
Mdga2provided by MGI
Official Full Name
MAM domain containing glycosylphosphatidylinositol anchor 2provided by MGI
Primary source
MGI:MGI:2444706
See related
Ensembl:ENSMUSG00000034912 Vega:OTTMUSG00000042300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adp; Mamdc1; 6720489L24Rik; 9330209L04Rik; Tg(Prnp-PFN1*G118V)838Kiaei
Expression
Biased expression in CNS E18 (RPKM 2.1), cortex adult (RPKM 1.5) and 7 other tissues See more
Orthologs

Genomic context

See Mdga2 in Genome Data Viewer
Location:
12 C2; 12 27.63 cM
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (66459419..67222549, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (67572169..68322190, complement)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene GC-rich promoter binding protein 1-like 1 pseudogene Neighboring gene ribosomal protein L10-like Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene Neighboring gene family with sequence similarity 20, member B pseudogene Neighboring gene ribosomal protein L17, pseudogene 3 Neighboring gene DDB1 and CUL4 associated factor 5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
GABA-ergic synapse EXP
Inferred from Experiment
more info
PubMed 
GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
Names
MAM domain containing 1
acrodysplasia

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193266.1NP_001180195.2  MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform A precursor

    See identical proteins and their annotated locations for NP_001180195.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AC164164, AK137667
    Consensus CDS
    CCDS56842.2
    UniProtKB/TrEMBL
    B2RQF5, Q3UV20
    Related
    ENSMUSP00000046761.10, OTTMUSP00000062253, ENSMUST00000037181.15, OTTMUST00000111280
    Conserved Domains (6) summary
    cd06263
    Location:748919
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    cd00096
    Location:355427
    Ig; Immunoglobulin domain
    smart00408
    Location:256317
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:48128
    IG_like; Immunoglobulin like
    pfam00629
    Location:748921
    MAM; MAM domain, meprin/A5/mu
    pfam13895
    Location:543618
    Ig_2; Immunoglobulin domain
  2. NM_207010.2NP_996893.3  MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform B precursor

    See identical proteins and their annotated locations for NP_996893.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) lacks an in-frame exon in the coding region, compared to variant A. The resulting protein (isoform B) is shorter, compared to isoform A.
    Source sequence(s)
    AC117250, AC125379, AC140249, AC164164
    Consensus CDS
    CCDS25945.1
    UniProtKB/Swiss-Prot
    P60755
    Related
    ENSMUSP00000152613.1, OTTMUSP00000062254, ENSMUST00000223141.1, OTTMUST00000111281
    Conserved Domains (6) summary
    cd06263
    Location:741912
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    cd00096
    Location:355427
    Ig; Immunoglobulin domain
    smart00408
    Location:256317
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:48128
    IG_like; Immunoglobulin like
    pfam00629
    Location:741914
    MAM; MAM domain, meprin/A5/mu
    pfam13895
    Location:543618
    Ig_2; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

    Range
    66459419..67222549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516013.2XP_006516076.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform X1

    Conserved Domains (4) summary
    smart00408
    Location:2788
    IGc2; Immunoglobulin C-2 Type
    pfam00629
    Location:519691
    MAM; MAM domain, meprin/A5/mu
    pfam13927
    Location:212287
    Ig_3; Immunoglobulin domain
    cl28434
    Location:120195
    I-set; Immunoglobulin I-set domain
  2. XM_011244127.2XP_011242429.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform X2

    Conserved Domains (3) summary
    cd00096
    Location:424496
    Ig; Immunoglobulin domain
    smart00408
    Location:325386
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:117197
    IG_like; Immunoglobulin like
  3. XM_006516014.3XP_006516077.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform X3

    Conserved Domains (3) summary
    cd00096
    Location:424496
    Ig; Immunoglobulin domain
    smart00408
    Location:325386
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:117197
    IG_like; Immunoglobulin like

RNA

  1. XR_872713.2 RNA Sequence

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